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    Epb41l4b erythrocyte membrane protein band 4.1 like 4b [ Mus musculus (house mouse) ]

    Gene ID: 54357, updated on 9-Sep-2018

    Summary

    Official Symbol
    Epb41l4bprovided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1 like 4bprovided by MGI
    Primary source
    MGI:MGI:1859149
    See related
    Ensembl:ENSMUSG00000028434 Vega:OTTMUSG00000007315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ehm2; Lulu2; AA589614; AU021054; BB007528; Epb4.1l4b; D4Ertd346e; 6430543G08Rik
    Expression
    Broad expression in large intestine adult (RPKM 21.1), colon adult (RPKM 11.0) and 20 other tissues See more
    Orthologs

    Genomic context

    See Epb41l4b in Genome Data Viewer
    Location:
    4 B3; 4 31.66 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (56992043..57143168, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (57074598..57156028, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ferric-chelate reductase 1 like Neighboring gene predicted gene, 34738 Neighboring gene translation initiation factor IF-2-like Neighboring gene predicted gene, 34802

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    band 4.1-like protein 4B
    Names
    erythrocyte protein band 4.1-like 4b
    erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells
    expressed in high-metastatic cells

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355492.1NP_001342421.1  band 4.1-like protein 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI835760, AK165783, AL831761, BB612044, CN710347
      Conserved Domains (3) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
    2. NM_019427.2NP_062300.2  band 4.1-like protein 4B isoform 1

      See identical proteins and their annotated locations for NP_062300.2

      Status: VALIDATED

      Source sequence(s)
      AK165783, AL831761, BB612044, CF915899
      Consensus CDS
      CCDS51180.1
      UniProtKB/Swiss-Prot
      Q9JMC8
      UniProtKB/TrEMBL
      Q3TMR3
      Related
      ENSMUSP00000030142.3, OTTMUSP00000007793, ENSMUST00000030142.3, OTTMUST00000016914
      Conserved Domains (5) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170277
      FERM_M; FERM central domain
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89151
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      56992043..57143168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250068.1XP_011248370.1  band 4.1-like protein 4B isoform X1

      Conserved Domains (5) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170277
      FERM_M; FERM central domain
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89151
      FERM_N; FERM N-terminal domain
    2. XM_006538087.3XP_006538150.1  band 4.1-like protein 4B isoform X2

      UniProtKB/TrEMBL
      A2ALK6
      Related
      ENSMUSP00000092687.3, OTTMUSP00000007794, ENSMUST00000095076.9, OTTMUST00000016915
      Conserved Domains (5) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170277
      FERM_M; FERM central domain
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89151
      FERM_N; FERM N-terminal domain
    3. XM_011250069.2XP_011248371.1  band 4.1-like protein 4B isoform X3

      Conserved Domains (6) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      pfam06495
      Location:332498
      Transformer; Fruit fly transformer protein
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170277
      FERM_M; FERM central domain
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89151
      FERM_N; FERM N-terminal domain
    4. XM_017320318.1XP_017175807.1  band 4.1-like protein 4B isoform X4

      Conserved Domains (3) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
    5. XM_006538089.3XP_006538152.1  band 4.1-like protein 4B isoform X5

      Conserved Domains (6) summary
      smart00295
      Location:87277
      B41; Band 4.1 homologues
      pfam06495
      Location:332498
      Transformer; Fruit fly transformer protein
      cd13186
      Location:273366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170277
      FERM_M; FERM central domain
      pfam08736
      Location:379419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89151
      FERM_N; FERM N-terminal domain
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