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    Atf7ip activating transcription factor 7 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 54343, updated on 18-Sep-2024

    Summary

    Official Symbol
    Atf7ipprovided by MGI
    Official Full Name
    activating transcription factor 7 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1858965
    See related
    Ensembl:ENSMUSG00000030213 AllianceGenome:MGI:1858965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AM; Mcaf1; 2610204M12Rik; 5830415B17Rik
    Summary
    Enables ATP hydrolysis activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; male reproductive gland or organ; and sensory organ. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.1), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atf7ip in Genome Data Viewer
    Location:
    6; 6 G1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136495787..136587848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136518789..136610850)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene predicted gene, 44140 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene phospholipase B domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activating transcription factor 7-interacting protein 1
    Names
    ATFa-associated Modulator
    MBD1-containing chromatin-associated factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388194.1NP_001375123.1  activating transcription factor 7-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:8691213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11991299
      fn3_4; Fibronectin-III type domain
    2. NM_001388195.1NP_001375124.1  activating transcription factor 7-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:8681212
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598811
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11981298
      fn3_4; Fibronectin-III type domain
    3. NM_001388196.1NP_001375125.1  activating transcription factor 7-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:8661208
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11941294
      fn3_4; Fibronectin-III type domain
    4. NM_001388197.1NP_001375126.1  activating transcription factor 7-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (3) summary
      PHA03247
      Location:271615
      PHA03247; large tegument protein UL36; Provisional
      pfam16788
      Location:3214
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:601701
      fn3_4; Fibronectin-III type domain
    5. NM_019426.3NP_062299.2  activating transcription factor 7-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_062299.2

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Consensus CDS
      CCDS20651.1
      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Related
      ENSMUSP00000032335.7, ENSMUST00000032335.13
      Conserved Domains (5) summary
      PHA03247
      Location:8661210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11961296
      fn3_4; Fibronectin-III type domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136495787..136587848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166296.1XP_036022189.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:8661210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11961296
      fn3_4; Fibronectin-III type domain
    2. XM_036166295.1XP_036022188.1  activating transcription factor 7-interacting protein 1 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:8691213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11991299
      fn3_4; Fibronectin-III type domain
    3. XM_017321681.3XP_017177170.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:8661210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11961296
      fn3_4; Fibronectin-III type domain
    4. XM_006506390.5XP_006506453.1  activating transcription factor 7-interacting protein 1 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:8771221
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:91370
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:298634
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:609820
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:12071307
      fn3_4; Fibronectin-III type domain
    5. XM_030255502.2XP_030111362.1  activating transcription factor 7-interacting protein 1 isoform X4

      Conserved Domains (5) summary
      PHA03247
      Location:8741218
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:91370
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:298631
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:606817
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:12041304
      fn3_4; Fibronectin-III type domain
    6. XM_006506388.5XP_006506451.2  activating transcription factor 7-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006506451.2

      Conserved Domains (5) summary
      PHA03247
      Location:8691213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11991299
      fn3_4; Fibronectin-III type domain
    7. XM_006506389.5XP_006506452.2  activating transcription factor 7-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006506452.2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:8661210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11961296
      fn3_4; Fibronectin-III type domain
    8. XM_036166294.1XP_036022187.1  activating transcription factor 7-interacting protein 1 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:8691213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11991299
      fn3_4; Fibronectin-III type domain
    9. XM_030255503.2XP_030111363.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:8661210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11961296
      fn3_4; Fibronectin-III type domain
    10. XM_006506392.3XP_006506455.1  activating transcription factor 7-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006506455.1

      Conserved Domains (5) summary
      PHA03247
      Location:8691213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:11991299
      fn3_4; Fibronectin-III type domain

    RNA

    1. XR_004942987.1 RNA Sequence

    2. XR_004942986.1 RNA Sequence