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    Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 54338, updated on 18-Sep-2018

    Summary

    Official Symbol
    Slc23a2provided by MGI
    Official Full Name
    solute carrier family 23 (nucleobase transporters), member 2provided by MGI
    Primary source
    MGI:MGI:1859682
    See related
    Ensembl:ENSMUSG00000027340 Vega:OTTMUSG00000015783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; AI844736; mKIAA0238
    Expression
    Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Slc23a2 in Genome Data Viewer
    Location:
    2; 2 F2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (132052496..132145320, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131878232..131970844, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene predicted gene, 39939 Neighboring gene predicted gene, 31179 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 14051 Neighboring gene predicted gene, 29720 Neighboring gene transmembrane protein 230

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-ascorbate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-ascorbate:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    L-ascorbate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    L-ascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-ascorbic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    L-ascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    sodium-dependent L-ascorbate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium-dependent L-ascorbate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    L-ascorbic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-ascorbic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    L-ascorbic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    transepithelial L-ascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transepithelial L-ascorbic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    contractile fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 23 member 2
    Names
    Na(+)/L-ascorbic acid transporter 2
    SVCT-2
    mSVCT2
    sodium-dependent vitamin C transporter 2
    solute carrier family 23 (nucleobase transporters), member 1
    yolk sac permease-like molecule 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355430.1NP_001342359.1  solute carrier family 23 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL831706, AL929513
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    2. NM_001355431.1NP_001342360.1  solute carrier family 23 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK087175
      Conserved Domains (1) summary
      cl23746
      Location:86156
      HCO3_cotransp; HCO3- transporter family
    3. NM_018824.2NP_061294.2  solute carrier family 23 member 2 isoform a

      See identical proteins and their annotated locations for NP_061294.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK087175, BC050823
      Consensus CDS
      CCDS16769.1
      UniProtKB/Swiss-Prot
      Q9EPR4
      Related
      ENSMUSP00000028815.8, OTTMUSP00000016807, ENSMUST00000028815.14, OTTMUST00000037505
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      132052496..132145320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239698.2XP_011238000.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_011238000.1

      UniProtKB/Swiss-Prot
      Q9EPR4
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    2. XM_006499906.3XP_006499969.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006499969.1

      UniProtKB/Swiss-Prot
      Q9EPR4
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    3. XM_006499907.3XP_006499970.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006499970.1

      UniProtKB/Swiss-Prot
      Q9EPR4
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    4. XM_017319131.1XP_017174620.1  solute carrier family 23 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9EPR4
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
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