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    Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 54338, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc23a2provided by MGI
    Official Full Name
    solute carrier family 23 (nucleobase transporters), member 2provided by MGI
    Primary source
    MGI:MGI:1859682
    See related
    Ensembl:ENSMUSG00000027340 AllianceGenome:MGI:1859682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; mKIAA0238
    Summary
    Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Acts upstream of or within blood circulation. Located in basal plasma membrane and cytoplasm. Is expressed in adrenal gland; central nervous system; liver; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc23a2 in Genome Data Viewer
    Location:
    2 F2; 2 64.15 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131894416..131987287, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132052496..132145320, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986 Neighboring gene STARR-positive B cell enhancer ABC_E10148 Neighboring gene STARR-positive B cell enhancer ABC_E8794 Neighboring gene STARR-positive B cell enhancer ABC_E8795 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05728 Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05733 Neighboring gene STARR-seq mESC enhancer starr_05734 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene transmembrane protein 230

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ascorbic acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-ascorbic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-ascorbic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-ascorbic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 23 member 2
    Names
    Na(+)/L-ascorbic acid transporter 2
    SVCT-2
    mSVCT2
    sodium-dependent vitamin C transporter 2
    solute carrier family 23 (nucleobase transporters), member 1
    yolk sac permease-like molecule 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355430.2NP_001342359.1  solute carrier family 23 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AL831706, AL929513
      Consensus CDS
      CCDS16769.1
      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    2. NM_001355431.2NP_001342360.1  solute carrier family 23 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL831706
      Related
      ENSMUST00000127724.8
      Conserved Domains (1) summary
      cl23746
      Location:86156
      HCO3_cotransp; HCO3- transporter family
    3. NM_001421503.1NP_001408432.1  solute carrier family 23 member 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL831706, AL929513
      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
    4. NM_001421504.1NP_001408433.1  solute carrier family 23 member 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL831706, AL929513
    5. NM_001421505.1NP_001408434.1  solute carrier family 23 member 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL831706
    6. NM_001421507.1NP_001408436.1  solute carrier family 23 member 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL831706
    7. NM_001421508.1NP_001408437.1  solute carrier family 23 member 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL831706
    8. NM_018824.3NP_061294.2  solute carrier family 23 member 2 isoform a

      See identical proteins and their annotated locations for NP_061294.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AL831706, AL929513
      Consensus CDS
      CCDS16769.1
      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
      Related
      ENSMUSP00000028815.9, ENSMUST00000028815.15
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family

    RNA

    1. NR_185307.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831706, AL929513

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131894416..131987287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239698.4XP_011238000.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_011238000.1

      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    2. XM_006499907.5XP_006499970.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006499970.1

      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    3. XM_030251882.2XP_030107742.1  solute carrier family 23 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y23, Q8C327, Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family