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    Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 54338, updated on 26-Sep-2022

    Summary

    Official Symbol
    Slc23a2provided by MGI
    Official Full Name
    solute carrier family 23 (nucleobase transporters), member 2provided by MGI
    Primary source
    MGI:MGI:1859682
    See related
    Ensembl:ENSMUSG00000027340 AllianceGenome:MGI:1859682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; mKIAA0238
    Summary
    Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane and cytoplasm. Is expressed in adrenal gland; central nervous system; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Slc23a2 in Genome Data Viewer
    Location:
    2; 2 F2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131894416..131987240, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132052496..132145320, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene predicted gene, 31179 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 14051 Neighboring gene predicted gene, 29720 Neighboring gene transmembrane protein 230

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbate:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-ascorbate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ascorbic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-ascorbic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-ascorbic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within carboxylic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monosaccharide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 23 member 2
    Names
    Na(+)/L-ascorbic acid transporter 2
    SVCT-2
    mSVCT2
    sodium-dependent vitamin C transporter 2
    solute carrier family 23 (nucleobase transporters), member 1
    yolk sac permease-like molecule 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355430.1NP_001342359.1  solute carrier family 23 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL831706, AL929513
      Consensus CDS
      CCDS16769.1
      UniProtKB/Swiss-Prot
      Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    2. NM_001355431.1NP_001342360.1  solute carrier family 23 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK087175
      Related
      ENSMUST00000127724.8
      Conserved Domains (1) summary
      cl23746
      Location:86156
      HCO3_cotransp; HCO3- transporter family
    3. NM_018824.2NP_061294.2  solute carrier family 23 member 2 isoform a

      See identical proteins and their annotated locations for NP_061294.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK087175, BC050823
      Consensus CDS
      CCDS16769.1
      UniProtKB/Swiss-Prot
      Q9EPR4, Q9JM78
      Related
      ENSMUSP00000028815.9, ENSMUST00000028815.15
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131894416..131987240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251883.2XP_030107743.1  solute carrier family 23 member 2 isoform X3

      Conserved Domains (1) summary
      cl23746
      Location:51374
      Xan_ur_permease; Permease family
    2. XM_011239698.4XP_011238000.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_011238000.1

      UniProtKB/Swiss-Prot
      Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    3. XM_006499906.4XP_006499969.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006499969.1

      UniProtKB/Swiss-Prot
      Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    4. XM_006499907.5XP_006499970.1  solute carrier family 23 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006499970.1

      UniProtKB/Swiss-Prot
      Q9EPR4, Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    5. XM_030251882.2XP_030107742.1  solute carrier family 23 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM78
      Conserved Domains (1) summary
      pfam00860
      Location:103529
      Xan_ur_permease; Permease family
    6. XM_036162398.1XP_036018291.1  solute carrier family 23 member 2 isoform X2

      Conserved Domains (1) summary
      pfam00860
      Location:47473
      Xan_ur_permease; Permease family