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    GNG2 G protein subunit gamma 2 [ Homo sapiens (human) ]

    Gene ID: 54331, updated on 17-Jun-2024

    Summary

    Official Symbol
    GNG2provided by HGNC
    Official Full Name
    G protein subunit gamma 2provided by HGNC
    Primary source
    HGNC:HGNC:4404
    See related
    Ensembl:ENSG00000186469 MIM:606981; AllianceGenome:HGNC:4404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG3F1
    Summary
    This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in brain (RPKM 43.3), spleen (RPKM 22.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GNG2 in Genome Data Viewer
    Location:
    14q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (51826174..51969795)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46033129..46176839)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52292892..52436513)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927598 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:52242760-52242929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8375 Neighboring gene olfactory receptor family 7 subfamily E member 106 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 159 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34233 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52282721-52283222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52326949-52327450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8384 Neighboring gene uncharacterized LOC102723604 Neighboring gene uncharacterized LOC105370497 Neighboring gene Sharpr-MPRA regulatory region 5932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:52480482-52481434 Neighboring gene RNA transcription, translation and transport factor Neighboring gene Sharpr-MPRA regulatory region 12958 Neighboring gene nidogen 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
    EBI GWAS Catalog
    Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to catecholamine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to prostaglandin E stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Names
    g gamma-I
    guanine nucleotide binding protein (G protein), gamma 2
    guanine nucleotide binding protein gamma 2
    guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit
    heterotrimeric guanine nucleotide-binding protein 3F1
    NP_001230702.1
    NP_001230703.1
    NP_001376636.1
    NP_001376637.1
    NP_001376638.1
    NP_001376639.1
    NP_444292.1
    XP_016876866.1
    XP_024305401.1
    XP_024305402.1
    XP_047287441.1
    XP_047287442.1
    XP_047287443.1
    XP_047287444.1
    XP_047287446.1
    XP_054232205.1
    XP_054232206.1
    XP_054232207.1
    XP_054232208.1
    XP_054232209.1
    XP_054232210.1
    XP_054232211.1
    XP_054232212.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243773.2NP_001230702.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_001230702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL358333, BQ025819, DA226565, DC318652
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    2. NM_001243774.2NP_001230703.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_001230703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL358333, BE245271, BQ025819, DC318652
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Related
      ENSP00000334448.4, ENST00000335281.8
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    3. NM_001389707.1NP_001376636.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL079307, AL358333
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    4. NM_001389708.1NP_001376637.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL079307, AL358333
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    5. NM_001389709.1NP_001376638.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL358333
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    6. NM_001389710.1NP_001376639.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL358333
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Related
      ENSP00000452014.1, ENST00000554736.5
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    7. NM_053064.5NP_444292.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_444292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL358333, BQ025819, DA785895, DC318652
      Consensus CDS
      CCDS32082.1
      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Related
      ENSP00000451231.1, ENST00000556766.6
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      51826174..51969795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431486.1XP_047287442.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    2. XM_017021377.2XP_016876866.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Related
      ENSP00000484021.1, ENST00000615906.4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    3. XM_024449633.2XP_024305401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    4. XM_024449634.2XP_024305402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    5. XM_047431490.1XP_047287446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    6. XM_047431488.1XP_047287444.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    7. XM_047431487.1XP_047287443.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    8. XM_047431485.1XP_047287441.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      46033129..46176839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376231.1XP_054232206.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    2. XM_054376235.1XP_054232210.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    3. XM_054376234.1XP_054232209.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    4. XM_054376237.1XP_054232212.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    5. XM_054376236.1XP_054232211.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    6. XM_054376233.1XP_054232208.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    7. XM_054376232.1XP_054232207.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

      UniProtKB/Swiss-Prot
      P59768, Q5JPE2, Q6P9A9
    8. XM_054376230.1XP_054232205.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1