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    Car3 carbonic anhydrase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54232, updated on 10-Jul-2024

    Summary

    Official Symbol
    Car3provided by RGD
    Official Full Name
    carbonic anhydrase 3provided by RGD
    Primary source
    RGD:2241
    See related
    EnsemblRapid:ENSRNOG00000010079 AllianceGenome:RGD:2241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca3
    Summary
    Enables phosphatase activity. Involved in response to ethanol and response to oxidative stress. Located in cytosol. Orthologous to human CA3 (carbonic anhydrase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 11846.3), Liver (RPKM 3098.3) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Car3 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (88491666..88501299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (86770418..86780011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (88126519..88136063, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5A-pseudogene 2 Neighboring gene carbonic anhydrase 2 Neighboring gene carbonic anhydrase 1 Neighboring gene carbonic anhydrase 13 Neighboring gene peroxiredoxin like 2A, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbonate dehydratase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nickel cation binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 3
    Names
    CA-III
    carbonate dehydratase III
    carbonic anhydrase III
    NP_062165.2
    XP_006232178.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019292.4NP_062165.2  carbonic anhydrase 3

      See identical proteins and their annotated locations for NP_062165.2

      Status: PROVISIONAL

      Source sequence(s)
      AB030830
      UniProtKB/Swiss-Prot
      O54961, P14141, Q9QV77
      UniProtKB/TrEMBL
      A0A8L2Q6S9, A6IH11
      Related
      ENSRNOP00000014177.5, ENSRNOT00000014180.8
      Conserved Domains (1) summary
      cd03119
      Location:1259
      alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      88491666..88501299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232116.3XP_006232178.1  carbonic anhydrase 3 isoform X1

      See identical proteins and their annotated locations for XP_006232178.1

      UniProtKB/Swiss-Prot
      O54961, P14141, Q9QV77
      UniProtKB/TrEMBL
      A0A8L2Q6S9, A6IH11
      Conserved Domains (1) summary
      cd03119
      Location:1259
      alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...