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    Cd320 CD320 antigen [ Mus musculus (house mouse) ]

    Gene ID: 54219, updated on 5-Mar-2019

    Summary

    Official Symbol
    Cd320provided by MGI
    Official Full Name
    CD320 antigenprovided by MGI
    Primary source
    MGI:MGI:1860083
    See related
    Ensembl:ENSMUSG00000002308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8D6; NG29; VLDL; TCblR; 425O18-1; D17Ertd716e
    Expression
    Broad expression in testis adult (RPKM 40.7), ovary adult (RPKM 24.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See Cd320 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (33843091..33849774)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (33980036..33986719)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S28 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene kinesin family member C1 Neighboring gene predicted gene, 27740 Neighboring gene pluripotency associated transcript 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cobalamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    cobalamin transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vitamin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD320 antigen
    Names
    putative VLDL lipoprotein receptor
    transcobalamin receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305169.1NP_001292098.1  CD320 antigen isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon, uses an alternate 5' terminal exon, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK078151, AK131655, AK140204
      Consensus CDS
      CCDS79533.1
      UniProtKB/Swiss-Prot
      Q9Z1P5
      Related
      ENSMUSP00000084839.7, ENSMUST00000087559.7
      Conserved Domains (1) summary
      cd00112
      Location:3368
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    2. NM_019421.3NP_062294.3  CD320 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_062294.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK078151, AK140204
      Consensus CDS
      CCDS28632.1
      UniProtKB/Swiss-Prot
      Q9Z1P5
      Related
      ENSMUSP00000002379.8, ENSMUST00000002379.14
      Conserved Domains (1) summary
      cd00112
      Location:4782
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      33843091..33849774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      91858..98541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      158533..165455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      158625..165567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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