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    PODXL podocalyxin like [ Homo sapiens (human) ]

    Gene ID: 5420, updated on 12-Oct-2019

    Summary

    Official Symbol
    PODXLprovided by HGNC
    Official Full Name
    podocalyxin likeprovided by HGNC
    Primary source
    HGNC:HGNC:9171
    See related
    Ensembl:ENSG00000128567 MIM:602632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PC; PCLP; Gp200; PCLP-1
    Summary
    This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 88.8), lung (RPKM 31.4) and 19 other tissues See more
    Orthologs

    Genomic context

    See PODXL in Genome Data Viewer
    Location:
    7q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (131500271..131556628, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (131185021..131241376, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene muskelin 1 Neighboring gene ribosomal protein L27 pseudogene 11 Neighboring gene MKLN1 antisense RNA Neighboring gene ribosomal protein L31 pseudogene 36 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 6 Neighboring gene ribosomal protein S14 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystem (from WikiPathways)
      Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystemPathway model based on hub miRNAs and their putative targets from network analysis. - From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carc...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138240

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial tube formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular visceral epithelial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell-cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microvillus assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space HDA PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microvillus membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    slit diaphragm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    podocalyxin
    Names
    GCTM-2 antigen
    podocalyxin-like protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042104.1 RefSeqGene

      Range
      4990..61347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018111.3NP_001018121.1  podocalyxin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001018121.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC008264, AK055816, AK223573, BC042466, BP355358, CN290641
      Consensus CDS
      CCDS34755.1
      UniProtKB/Swiss-Prot
      O00592
      UniProtKB/TrEMBL
      Q96N83
      Related
      ENSP00000367817.3, ENST00000378555.8
      Conserved Domains (1) summary
      pfam06365
      Location:358557
      CD34_antigen; CD34/Podocalyxin family
    2. NM_005397.4NP_005388.2  podocalyxin isoform 2 precursor

      See identical proteins and their annotated locations for NP_005388.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame alternate exon compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC008264, AK055816, AK223573, BC042466, BP355358
      Consensus CDS
      CCDS47714.1
      UniProtKB/Swiss-Prot
      O00592
      UniProtKB/TrEMBL
      Q96N83
      Related
      ENSP00000319782.9, ENST00000322985.9
      Conserved Domains (2) summary
      pfam06365
      Location:326525
      CD34_antigen; CD34/Podocalyxin family
      cl25496
      Location:33293
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      131500271..131556628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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