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    Pabpn1 poly(A) binding protein, nuclear 1 [ Mus musculus (house mouse) ]

    Gene ID: 54196, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pabpn1provided by MGI
    Official Full Name
    poly(A) binding protein, nuclear 1provided by MGI
    Primary source
    MGI:MGI:1859158
    See related
    Ensembl:ENSMUSG00000022194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAB2; Pabp3; mPABII
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 169.0), CNS E14 (RPKM 167.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pabpn1 in Genome Data Viewer
    Location:
    14 C2; 14 27.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (54894143..54898927)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (55512980..55517764)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene embryonal Fyn-associated substrate

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA polyadenylation TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of polynucleotide adenylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyadenylate-binding protein 2
    Names
    PABII
    PABP-2
    nuclear poly(A)-binding protein 1
    poly(A) binding protein II
    poly(A)-binding protein 2
    polyadenylate-binding nuclear protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019402.2NP_062275.1  polyadenylate-binding protein 2

      See identical proteins and their annotated locations for NP_062275.1

      Status: VALIDATED

      Source sequence(s)
      AC116591, AK032172, BY266376
      Consensus CDS
      CCDS27104.1
      UniProtKB/Swiss-Prot
      Q8CCS6
      Related
      ENSMUSP00000022808.7, ENSMUST00000022808.13
      Conserved Domains (2) summary
      COG0724
      Location:109285
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:169244
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      54894143..54898927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519272.3XP_006519335.1  polyadenylate-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      G3UWS5
      Related
      ENSMUSP00000133405.1, ENSMUST00000172557.1
      Conserved Domains (2) summary
      COG0724
      Location:13161
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:45120
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
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