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    Kat6b K(lysine) acetyltransferase 6B [ Mus musculus (house mouse) ]

    Gene ID: 54169, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kat6bprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 6Bprovided by MGI
    Primary source
    MGI:MGI:1858746
    See related
    Ensembl:ENSMUSG00000021767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mo; qkf; Morf; Myst; Myst4; querk; MYST-4; AI507552; querkopf; mKIAA0383; B130044K16Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kat6b in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21549284..21722546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21499216..21672478)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (22319076..22491355)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene predicted gene, 30363 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase and pro isomerase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT6B
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MYST histone acetyltransferase monocytic leukemia 4
    histone acetyltransferase MYST4
    histone acetyltransferase querkopf
    monocytic leukemia
    protein querkopf
    NP_001192170.1
    NP_059507.2
    XP_006519326.1
    XP_006519327.1
    XP_006519328.1
    XP_006519331.1
    XP_006519332.1
    XP_017171571.1
    XP_017171572.1
    XP_017171573.1
    XP_030103747.1
    XP_030103748.1
    XP_036014649.1
    XP_036014650.1
    XP_036014651.1
    XP_036014652.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205241.1NP_001192170.1  histone acetyltransferase KAT6B

      See identical proteins and their annotated locations for NP_001192170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148978, AK147509, BP753863
      Consensus CDS
      CCDS59615.1
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138511.2, ENSMUST00000182855.8
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    2. NM_017479.3NP_059507.2  histone acetyltransferase KAT6B

      See identical proteins and their annotated locations for NP_059507.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115122, AC148978, AK052307, BC095974, BP753863
      Consensus CDS
      CCDS59615.1
      UniProtKB/Swiss-Prot
      Q8BRB7
      UniProtKB/TrEMBL
      Q501M5
      Related
      ENSMUSP00000138377.2, ENSMUST00000182405.9
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21549284..21722546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519265.5XP_006519328.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519328.1

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    2. XM_036158758.1XP_036014651.1  histone acetyltransferase KAT6B isoform X6

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    3. XM_006519264.5XP_006519327.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519327.1

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    4. XM_036158756.1XP_036014649.1  histone acetyltransferase KAT6B isoform X1

      Related
      ENSMUSP00000159058.2, ENSMUST00000238837.2
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    5. XM_036158759.1XP_036014652.1  histone acetyltransferase KAT6B isoform X7

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    6. XM_030247887.2XP_030103747.1  histone acetyltransferase KAT6B isoform X1

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    7. XM_017316082.3XP_017171571.1  histone acetyltransferase KAT6B isoform X2

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    8. XM_006519263.5XP_006519326.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519326.1

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    9. XM_036158757.1XP_036014650.1  histone acetyltransferase KAT6B isoform X3

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:584852
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    10. XM_006519268.5XP_006519331.1  histone acetyltransferase KAT6B isoform X4

      See identical proteins and their annotated locations for XP_006519331.1

      UniProtKB/Swiss-Prot
      Q8BRB7
      Related
      ENSMUSP00000138421.2, ENSMUST00000182964.3
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:539807
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    11. XM_017316083.3XP_017171572.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/Swiss-Prot
      Q8BRB7
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    12. XM_017316084.3XP_017171573.1  histone acetyltransferase KAT6B isoform X7

      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    13. XM_006519269.5XP_006519332.1  histone acetyltransferase KAT6B isoform X5

      Conserved Domains (2) summary
      PLN00104
      Location:436704
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:133
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    14. XM_030247888.2XP_030103748.1  histone acetyltransferase KAT6B isoform X8

      Conserved Domains (1) summary
      PLN00104
      Location:557
      PLN00104; MYST -like histone acetyltransferase; Provisional
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