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    Cyhr1 cysteine and histidine rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 54151, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cyhr1provided by MGI
    Official Full Name
    cysteine and histidine rich 1provided by MGI
    Primary source
    MGI:MGI:1859320
    See related
    Ensembl:ENSMUSG00000053929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ch; Chrp; AU042374; 1110031M01Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 18.7), ovary adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cyhr1 in Genome Data Viewer
    Location:
    15; 15 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76527595..76544408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76643395..76660208, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76476197..76490538, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 28 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine and histidine-rich protein 1
    Names
    cysteine and histidine-rich cytoplasmic protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276321.1NP_001263250.1  cysteine and histidine-rich protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate 5' and 3' exon structure, and differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (3) is longer and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK211953, AW455382, BX512375, BX522828, BY287678, CJ105770
      Consensus CDS
      CCDS70643.1
      UniProtKB/TrEMBL
      H3BIV6
      Related
      ENSMUSP00000134739.2, ENSMUST00000176274.2
      Conserved Domains (1) summary
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    2. NM_001276322.1NP_001263251.1  cysteine and histidine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001263251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate 3' exon structure, and differs in the central and 3' coding regions, compared to variant 1. Variants 2, 4, 5, 6 and 7 encode the same isoform (2), which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC156550, AI425234, AK004009, BY098544
      Consensus CDS
      CCDS27582.1
      UniProtKB/Swiss-Prot
      Q9QXA1
      Related
      ENSMUSP00000135505.2, ENSMUST00000177359.2
    3. NM_001276333.1NP_001263262.1  cysteine and histidine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001263262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate 5' and 3' exon structure, and differs in both UTRs and in the central and 3' coding regions, compared to variant 1. Variants 2, 4, 5, 6 and 7 encode the same isoform (2), which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC156550, AI425234, AK004009, BG087565
      Consensus CDS
      CCDS27582.1
      UniProtKB/Swiss-Prot
      Q9QXA1
      Related
      ENSMUSP00000155579.2, ENSMUST00000231152.2
    4. NM_001276334.1NP_001263263.1  cysteine and histidine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001263263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses alternate 5' and 3' exon structure, and differs in both UTRs and in the central and 3' coding regions, compared to variant 1. Variants 2, 4, 5, 6 and 7 encode the same isoform (2), which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI425234, AK004009, BB849289, BE859486, BG087565
      Consensus CDS
      CCDS27582.1
      UniProtKB/Swiss-Prot
      Q9QXA1
    5. NM_001276335.1NP_001263264.1  cysteine and histidine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001263264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses alternate 5' and 3' exon structure, and differs in both UTRs and in the central and 3' coding regions, compared to variant 1. Variants 2, 4, 5, 6 and 7 encode the same isoform (2), which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI425234, AK004009, BE859486
      Consensus CDS
      CCDS27582.1
      UniProtKB/Swiss-Prot
      Q9QXA1
    6. NM_001357882.1NP_001344811.1  cysteine and histidine-rich protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AC156550
      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    7. NM_019396.3NP_062269.1  cysteine and histidine-rich protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_062269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC156550, AK004009, BE653118, BM939179, BY098544, CF740409, CF742880, CN527531
      Consensus CDS
      CCDS27581.1
      UniProtKB/Swiss-Prot
      Q9QXA1
      Related
      ENSMUSP00000080043.7, ENSMUST00000081291.13
      Conserved Domains (2) summary
      cl17238
      Location:3163
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl19105
      Location:73134
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    8. NM_180962.2NP_851293.1  cysteine and histidine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_851293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate 3' exon structure, and differs in the central and 3' coding regions, compared to variant 1. Variants 2, 4, 5, 6 and 7 encode the same isoform (2), which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC156550, AI425234, AK004009, BY098544
      Consensus CDS
      CCDS27582.1
      UniProtKB/Swiss-Prot
      Q9QXA1
      Related
      ENSMUSP00000063317.9, ENSMUST00000066677.10

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76527595..76544408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521167.4XP_006521230.1  cysteine and histidine-rich protein 1 isoform X1

      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    2. XM_006521169.4XP_006521232.1  cysteine and histidine-rich protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006521232.1

      UniProtKB/Swiss-Prot
      Q9QXA1
      Conserved Domains (2) summary
      cl17238
      Location:3163
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl19105
      Location:73134
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    3. XM_006521168.4XP_006521231.1  cysteine and histidine-rich protein 1 isoform X2

      Related
      ENSMUSP00000155816.2, ENSMUST00000229524.2
      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    4. XM_030248659.2XP_030104519.1  cysteine and histidine-rich protein 1 isoform X3

    5. XM_030248660.2XP_030104520.1  cysteine and histidine-rich protein 1 isoform X3

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