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    Cyhr1 cysteine and histidine rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 54151, updated on 26-Sep-2022

    Summary

    Official Symbol
    Cyhr1provided by MGI
    Official Full Name
    cysteine and histidine rich 1provided by MGI
    Primary source
    MGI:MGI:1859320
    See related
    Ensembl:ENSMUSG00000053929 AllianceGenome:MGI:1859320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chrp; Zftraf1; 1110031M01Rik
    Summary
    Predicted to enable zinc ion binding activity. Located in cytoplasm and nuclear envelope. Orthologous to human CYHR1 (cysteine and histidine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.7), ovary adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cyhr1 in Genome Data Viewer
    Location:
    15; 15 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76527595..76544408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76643395..76660208, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 28 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Tmem276-zftraf1

    Readthrough gene: Tmem276-zftraf1, Included gene: Tmem276

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine and histidine-rich protein 1
    Names
    cysteine and histidine-rich cytoplasmic protein
    zinc finger TRAF-type containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276321.2NP_001263250.1  cysteine and histidine-rich protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS70643.1
      UniProtKB/TrEMBL
      H3BIV6
      Related
      ENSMUSP00000134739.2, ENSMUST00000176274.2
      Conserved Domains (1) summary
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    2. NM_001357882.2NP_001344811.1  cysteine and histidine-rich protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      A0A6P5R4W3
      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    3. NM_001408103.1NP_001395032.1  cysteine and histidine-rich protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550
    4. NM_001408104.1NP_001395033.1  cysteine and histidine-rich protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156550
    5. NM_001408207.1NP_001395136.1  cysteine and histidine-rich protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156550
    6. NM_001408208.1NP_001395137.1  cysteine and histidine-rich protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76527595..76544408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521167.4XP_006521230.1  cysteine and histidine-rich protein 1 isoform X1

      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    2. XM_006521169.4XP_006521232.1  cysteine and histidine-rich protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006521232.1

      UniProtKB/Swiss-Prot
      Q9D134, Q9QXA1
      UniProtKB/TrEMBL
      A0A6P5QXS5, A0A8C6I0P1
      Conserved Domains (2) summary
      cl17238
      Location:3163
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl19105
      Location:73134
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    3. XM_006521168.4XP_006521231.1  cysteine and histidine-rich protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8VI70
      Related
      ENSMUSP00000155816.2, ENSMUST00000229524.2
      Conserved Domains (2) summary
      cd16505
      Location:103151
      RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
      cl19105
      Location:161222
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    4. XM_030248659.2XP_030104519.1  cysteine and histidine-rich protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C6N1L1
    5. XM_030248660.2XP_030104520.1  cysteine and histidine-rich protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C6N1L1