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    Arhgef7 Rho guanine nucleotide exchange factor (GEF7) [ Mus musculus (house mouse) ]

    Gene ID: 54126, updated on 16-Oct-2021

    Summary

    Official Symbol
    Arhgef7provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF7)provided by MGI
    Primary source
    MGI:MGI:1860493
    See related
    Ensembl:ENSMUSG00000031511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; beta-Pix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.8), whole brain E14.5 (RPKM 14.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgef7 in Genome Data Viewer
    Location:
    8; 8 A1.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11778053..11885219)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11728001..11835219)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (11728105..11835219)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700128E19 gene Neighboring gene katanin p60 (ATPase-containing) subunit A1 pseudogene Neighboring gene predicted gene 45420 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene testis expressed 29 Neighboring gene high mobility group box 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity HMP PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in storage vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 7
    Names
    PAK-interacting exchange factor beta
    Pak3 binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113517.2NP_001106989.1  rho guanine nucleotide exchange factor 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Consensus CDS
      CCDS52480.1
      UniProtKB/Swiss-Prot
      Q9ES28
      Related
      ENSMUSP00000106534.3, ENSMUST00000110909.9
      Conserved Domains (7) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:3107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:477557
      PH; PH domain
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    2. NM_001113518.2NP_001106990.1  rho guanine nucleotide exchange factor 7 isoform b

      See identical proteins and their annotated locations for NP_001106990.1

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Consensus CDS
      CCDS52481.1
      UniProtKB/Swiss-Prot
      Q9ES28
      Related
      ENSMUSP00000096538.3, ENSMUST00000098938.9
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:320400
      PH; PH domain
      pfam16523
      Location:616702
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    3. NM_001372321.1NP_001359250.1  rho guanine nucleotide exchange factor 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (7) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:3107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:773859
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    4. NM_001372322.1NP_001359251.1  rho guanine nucleotide exchange factor 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (7) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:3107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:714800
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    5. NM_001372323.1NP_001359252.1  rho guanine nucleotide exchange factor 7 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (6) summary
      cd12061
      Location:85138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:632718
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:531629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:3581
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    6. NM_001372324.1NP_001359253.1  rho guanine nucleotide exchange factor 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    7. NM_001372325.1NP_001359254.1  rho guanine nucleotide exchange factor 7 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:93270
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:301399
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:556642
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:455553
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    8. NM_001372326.1NP_001359255.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Conserved Domains (4) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    9. NM_017402.5NP_059098.2  rho guanine nucleotide exchange factor 7 isoform c

      See identical proteins and their annotated locations for NP_059098.2

      Status: VALIDATED

      Source sequence(s)
      AC120785, AC126800
      Consensus CDS
      CCDS22099.1
      UniProtKB/Swiss-Prot
      Q9ES28
      UniProtKB/TrEMBL
      A0A0R4J0X8
      Related
      ENSMUSP00000074399.7, ENSMUST00000074856.13
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      11778053..11885219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154166.1XP_036010059.1  rho guanine nucleotide exchange factor 7 isoform X1

      Conserved Domains (7) summary
      cd12061
      Location:224277
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:308485
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:516614
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:670768
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:830916
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:174220
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:3172
      CH_SF; calponin homology (CH) domain superfamily
    2. XM_036154167.1XP_036010060.1  rho guanine nucleotide exchange factor 7 isoform X2

      Conserved Domains (7) summary
      cd12061
      Location:224277
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:308485
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:516614
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:670768
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:771857
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:174220
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:3172
      CH_SF; calponin homology (CH) domain superfamily
    3. XM_036154168.1XP_036010061.1  rho guanine nucleotide exchange factor 7 isoform X3

      Conserved Domains (7) summary
      cd12061
      Location:224277
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:308485
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:516614
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:633693
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:755841
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:174220
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:3172
      CH_SF; calponin homology (CH) domain superfamily
    4. XM_036154170.1XP_036010063.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (7) summary
      cd12061
      Location:224277
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:308485
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:516614
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:633693
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:696782
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:174220
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:3172
      CH_SF; calponin homology (CH) domain superfamily
    5. XM_036154169.1XP_036010062.1  rho guanine nucleotide exchange factor 7 isoform X4

      Conserved Domains (7) summary
      cd12061
      Location:138191
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:222399
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:430528
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:584682
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:744830
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:88134
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:386
      CH_SF; calponin homology (CH) domain superfamily
    6. XM_030243677.2XP_030099537.1  rho guanine nucleotide exchange factor 7 isoform X9

      Conserved Domains (4) summary
      cd00160
      Location:1134
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:165263
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:479565
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:319417
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    7. XM_036154173.1XP_036010066.1  rho guanine nucleotide exchange factor 7 isoform X8

      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:419479
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:482568
      betaPIX_CC; betaPIX coiled coil
    8. XM_036154175.1XP_036010068.1  rho guanine nucleotide exchange factor 7 isoform X11

      Conserved Domains (3) summary
      cd00160
      Location:1134
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:165263
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:319417
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    9. XM_036154174.1XP_036010067.1  rho guanine nucleotide exchange factor 7 isoform X10

      Conserved Domains (4) summary
      cd00160
      Location:1134
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:165263
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:319417
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:420506
      betaPIX_CC; betaPIX coiled coil
    10. XM_006508845.5XP_006508908.1  rho guanine nucleotide exchange factor 7 isoform X6

      Conserved Domains (6) summary
      cd12061
      Location:85138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:691777
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:531629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:3581
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    11. XM_036154171.1XP_036010064.1  rho guanine nucleotide exchange factor 7 isoform X7

      Conserved Domains (4) summary
      cd00160
      Location:17192
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:223321
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:377475
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:537623
      betaPIX_CC; betaPIX coiled coil
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