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    Cks1b CDC28 protein kinase 1b [ Mus musculus (house mouse) ]

    Gene ID: 54124, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cks1bprovided by MGI
    Official Full Name
    CDC28 protein kinase 1bprovided by MGI
    Primary source
    MGI:MGI:1889208
    See related
    Ensembl:ENSMUSG00000028044 AllianceGenome:MGI:1889208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cks1; sid1334; 2410005G18Rik; 2610005D03Rik
    Summary
    Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Acts upstream of or within fibroblast proliferation; mitotic cell cycle phase transition; and regulation of DNA-templated transcription. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; limb; and neural retina. Orthologous to human CKS1B (CDC28 protein kinase regulatory subunit 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 95.5), CNS E11.5 (RPKM 87.4) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Cks1b in Genome Data Viewer
    Location:
    3 F1; 3 39.11 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89322779..89325598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89415472..89418291, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene lens epithelial protein Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E70 Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene src homology 2 domain-containing transforming protein C1 Neighboring gene pygopus 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle phase transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinases regulatory subunit 1
    Names
    CKS-1
    cyclin-dependent kinase regulatory subunit 1
    sid 1334

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016904.1NP_058600.1  cyclin-dependent kinases regulatory subunit 1

      See identical proteins and their annotated locations for NP_058600.1

      Status: PROVISIONAL

      Source sequence(s)
      AB025409
      Consensus CDS
      CCDS38493.1
      UniProtKB/Swiss-Prot
      P61025, Q6ZWX7
      UniProtKB/TrEMBL
      Q9D0L3
      Related
      ENSMUSP00000029679.4, ENSMUST00000029679.4
      Conserved Domains (1) summary
      pfam01111
      Location:873
      CKS; Cyclin-dependent kinase regulatory subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89322779..89325598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)