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    ATP7B ATPase copper transporting beta [ Homo sapiens (human) ]

    Gene ID: 540, updated on 5-Aug-2022

    Summary

    Official Symbol
    ATP7Bprovided by HGNC
    Official Full Name
    ATPase copper transporting betaprovided by HGNC
    Primary source
    HGNC:HGNC:870
    See related
    Ensembl:ENSG00000123191 MIM:606882; AllianceGenome:HGNC:870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WD; PWD; WC1; WND
    Summary
    This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]
    Expression
    Broad expression in testis (RPKM 5.6), duodenum (RPKM 4.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ATP7B in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (51932669..52012132, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51147339..51226266, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52506805..52585586, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 272 Neighboring gene coiled-coil domain containing 70 Neighboring gene CTAGE family member 3, pseudogene Neighboring gene fatty acid binding protein 5 pseudogene 2 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene UTP14C small subunit processome component Neighboring gene NIMA related kinase 5 Neighboring gene Sharpr-MPRA regulatory region 10224

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type divalent copper transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables P-type divalent copper transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables P-type divalent copper transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables P-type divalent copper transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables P-type monovalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular copper ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular zinc ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in copper ion export IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in copper ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in copper ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in copper ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation by copper ion transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to copper ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sequestering of calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    copper-transporting ATPase 2
    Names
    ATPase, Cu(2+)- transporting, beta polypeptide
    ATPase, Cu++ transporting, beta polypeptide
    Wilson disease-associated protein
    copper pump 2
    copper-transporting protein ATP7B
    NP_000044.2
    NP_001005918.1
    NP_001230111.1
    NP_001317507.1
    NP_001317508.1
    XP_005266480.1
    XP_005266481.1
    XP_005266487.1
    XP_005266488.1
    XP_006719900.1
    XP_011533419.1
    XP_016876116.1
    XP_047286341.1
    XP_047286342.1
    XP_047286343.1
    XP_047286344.1
    XP_047286345.1
    XP_047286346.1
    XP_047286347.1
    XP_047286348.1
    XP_047286349.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008806.1 RefSeqGene

      Range
      5045..83826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000053.4NP_000044.2  copper-transporting ATPase 2 isoform a

      See identical proteins and their annotated locations for NP_000044.2

      Status: REVIEWED

      Source sequence(s)
      AL162377, BC143976, BU682287, DA125470, U11700
      Consensus CDS
      CCDS41892.1
      UniProtKB/Swiss-Prot
      P35670, Q5T7X7
      UniProtKB/TrEMBL
      A0A024RDX3, B7ZLR4
      Related
      ENSP00000242839.5, ENST00000242839.10
      Conserved Domains (4) summary
      COG2217
      Location:5661355
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:12061309
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:363425
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:7691016
      E1-E2_ATPase; E1-E2 ATPase
    2. NM_001005918.3NP_001005918.1  copper-transporting ATPase 2 isoform b

      See identical proteins and their annotated locations for NP_001005918.1

      Status: REVIEWED

      Source sequence(s)
      AL162377, BC143976, BU682287, DA125470
      Consensus CDS
      CCDS45049.1
      UniProtKB/TrEMBL
      B7ZLR4
      Related
      ENSP00000342559.5, ENST00000344297.9
      Conserved Domains (4) summary
      COG2217
      Location:3601148
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:9991102
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:363425
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:621809
      E1-E2_ATPase; E1-E2 ATPase
    3. NM_001243182.2NP_001230111.1  copper-transporting ATPase 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL162377, BC143976, BU682287, DA125470, DQ015922
      Consensus CDS
      CCDS58293.1
      UniProtKB/Swiss-Prot
      P35670
      UniProtKB/TrEMBL
      B7ZLR4
      Related
      ENSP00000383217.3, ENST00000400366.6
      Conserved Domains (4) summary
      COG2217
      Location:4551244
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:10951198
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:146209
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:658905
      E1-E2_ATPase; E1-E2 ATPase
    4. NM_001330578.2NP_001317507.1  copper-transporting ATPase 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL162377, BC143975, BC143976, BU682287, DA125470, U11700
      Consensus CDS
      CCDS81768.1
      UniProtKB/Swiss-Prot
      P35670
      UniProtKB/TrEMBL
      B7ZLR3, B7ZLR4, E7ET55
      Related
      ENSP00000501168.1, ENST00000673772.1
      Conserved Domains (4) summary
      COG2217
      Location:5661277
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11281231
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:363425
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:694938
      E1-E2_ATPase; E1-E2 ATPase
    5. NM_001330579.2NP_001317508.1  copper-transporting ATPase 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL162377, BC143976, BU682287, DA125470, U11700
      UniProtKB/Swiss-Prot
      P35670
      UniProtKB/TrEMBL
      B7ZLR4
      Related
      ENSP00000416738.3, ENST00000448424.7
      Conserved Domains (4) summary
      COG4087
      Location:11221225
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:363425
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      TIGR01511
      Location:6261271
      ATPase-IB1_Cu; copper-(or silver)-translocating P-type ATPase
      pfam00122
      Location:685932
      E1-E2_ATPase; E1-E2 ATPase
    6. NM_001406511.1NP_001393440.1  copper-transporting ATPase 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
      UniProtKB/Swiss-Prot
      Q5T7X7
    7. NM_001406512.1NP_001393441.1  copper-transporting ATPase 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
      UniProtKB/Swiss-Prot
      Q5T7X7
    8. NM_001406513.1NP_001393442.1  copper-transporting ATPase 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    9. NM_001406514.1NP_001393443.1  copper-transporting ATPase 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    10. NM_001406515.1NP_001393444.1  copper-transporting ATPase 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    11. NM_001406516.1NP_001393445.1  copper-transporting ATPase 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    12. NM_001406517.1NP_001393446.1  copper-transporting ATPase 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL162377
    13. NM_001406518.1NP_001393447.1  copper-transporting ATPase 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    14. NM_001406519.1NP_001393448.1  copper-transporting ATPase 2 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    15. NM_001406520.1NP_001393449.1  copper-transporting ATPase 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    16. NM_001406521.1NP_001393450.1  copper-transporting ATPase 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    17. NM_001406522.1NP_001393451.1  copper-transporting ATPase 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    18. NM_001406523.1NP_001393452.1  copper-transporting ATPase 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    19. NM_001406524.1NP_001393453.1  copper-transporting ATPase 2 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    20. NM_001406525.1NP_001393454.1  copper-transporting ATPase 2 isoform n

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    21. NM_001406526.1NP_001393455.1  copper-transporting ATPase 2 isoform o

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    22. NM_001406527.1NP_001393456.1  copper-transporting ATPase 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    23. NM_001406528.1NP_001393457.1  copper-transporting ATPase 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    24. NM_001406530.1NP_001393459.1  copper-transporting ATPase 2 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL162377
    25. NM_001406531.1NP_001393460.1  copper-transporting ATPase 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    26. NM_001406532.1NP_001393461.1  copper-transporting ATPase 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    27. NM_001406534.1NP_001393463.1  copper-transporting ATPase 2 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    28. NM_001406535.1NP_001393464.1  copper-transporting ATPase 2 isoform r

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    29. NM_001406536.1NP_001393465.1  copper-transporting ATPase 2 isoform s

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL162377
    30. NM_001406537.1NP_001393466.1  copper-transporting ATPase 2 isoform t

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    31. NM_001406538.1NP_001393467.1  copper-transporting ATPase 2 isoform u

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    32. NM_001406539.1NP_001393468.1  copper-transporting ATPase 2 isoform v

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    33. NM_001406540.1NP_001393469.1  copper-transporting ATPase 2 isoform w

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    34. NM_001406541.1NP_001393470.1  copper-transporting ATPase 2 isoform x

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    35. NM_001406542.1NP_001393471.1  copper-transporting ATPase 2 isoform x

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    36. NM_001406543.1NP_001393472.1  copper-transporting ATPase 2 isoform y

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    37. NM_001406544.1NP_001393473.1  copper-transporting ATPase 2 isoform z

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL162377
    38. NM_001406545.1NP_001393474.1  copper-transporting ATPase 2 isoform aa

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    39. NM_001406546.1NP_001393475.1  copper-transporting ATPase 2 isoform bb

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    40. NM_001406547.1NP_001393476.1  copper-transporting ATPase 2 isoform cc

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377
    41. NM_001406548.1NP_001393477.1  copper-transporting ATPase 2 isoform dd

      Status: REVIEWED

      Source sequence(s)
      AL138821, AL139082, AL162377

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      51932669..52012132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430389.1XP_047286345.1  copper-transporting ATPase 2 isoform X8

    2. XM_047430388.1XP_047286344.1  copper-transporting ATPase 2 isoform X7

    3. XM_047430387.1XP_047286343.1  copper-transporting ATPase 2 isoform X6

    4. XM_005266430.5XP_005266487.1  copper-transporting ATPase 2 isoform X1

      UniProtKB/Swiss-Prot
      P35670
      UniProtKB/TrEMBL
      A0A024RDX3
      Conserved Domains (4) summary
      COG2217
      Location:5661355
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:12061309
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:363425
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:7691016
      E1-E2_ATPase; E1-E2 ATPase
    5. XM_047430385.1XP_047286341.1  copper-transporting ATPase 2 isoform X4

    6. XM_047430386.1XP_047286342.1  copper-transporting ATPase 2 isoform X5

    7. XM_011535117.4XP_011533419.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_011533419.1

      Conserved Domains (4) summary
      COG2217
      Location:5341323
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11741277
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:331393
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:737984
      E1-E2_ATPase; E1-E2 ATPase
    8. XM_005266431.5XP_005266488.1  copper-transporting ATPase 2 isoform X2

      Conserved Domains (4) summary
      COG2217
      Location:5541343
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11941297
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:351413
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:7571004
      E1-E2_ATPase; E1-E2 ATPase
    9. XM_006719837.4XP_006719900.1  copper-transporting ATPase 2 isoform X3

      Conserved Domains (4) summary
      COG2217
      Location:5341323
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11741277
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:331393
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:737984
      E1-E2_ATPase; E1-E2 ATPase
    10. XM_017020627.2XP_016876116.1  copper-transporting ATPase 2 isoform X3

      Conserved Domains (4) summary
      COG2217
      Location:5341323
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11741277
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:331393
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:737984
      E1-E2_ATPase; E1-E2 ATPase
    11. XM_005266424.5XP_005266481.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_005266481.1

      Conserved Domains (4) summary
      COG2217
      Location:5341323
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11741277
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:331393
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:737984
      E1-E2_ATPase; E1-E2 ATPase
    12. XM_005266423.3XP_005266480.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_005266480.1

      Conserved Domains (4) summary
      COG2217
      Location:5341323
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:11741277
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:331393
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:737984
      E1-E2_ATPase; E1-E2 ATPase
    13. XM_047430390.1XP_047286346.1  copper-transporting ATPase 2 isoform X9

    14. XM_047430391.1XP_047286347.1  copper-transporting ATPase 2 isoform X10

    15. XM_047430393.1XP_047286349.1  copper-transporting ATPase 2 isoform X12

    16. XM_047430392.1XP_047286348.1  copper-transporting ATPase 2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      51147339..51226266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)