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    ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens (human) ]

    Gene ID: 54, updated on 19-Jul-2021

    Summary

    Official Symbol
    ACP5provided by HGNC
    Official Full Name
    acid phosphatase 5, tartrate resistantprovided by HGNC
    Primary source
    HGNC:HGNC:124
    See related
    Ensembl:ENSG00000102575 MIM:171640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPAP; TRAP; TRACP5a; TRACP5b; TrATPase
    Summary
    This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
    Expression
    Broad expression in lung (RPKM 55.0), kidney (RPKM 29.2) and 16 other tissues See more
    Orthologs
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    Genomic context

    See ACP5 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11574660..11578983, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11685475..11689790, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene elongation factor 1 homolog Neighboring gene zinc finger protein 627 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene vomeronasal 2 receptor 12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    GeneReviews: Not available
    Spondyloenchondrodysplasia with immune dysregulation
    MedGen: C1842763 OMIM: 607944 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of acid phosphatase 5, tartrate resistant (ACP5) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117378

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tartrate-resistant acid phosphatase type 5
    Names
    human purple acid phosphatase
    tartrate-resistant acid ATPase
    tartrate-resistant acid phosphatase 5a
    tartrate-resistant acid phosphatase 5b
    NP_001104504.1
    NP_001104505.1
    NP_001104506.1
    NP_001308952.1
    NP_001602.1
    XP_005259995.1
    XP_011526371.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028127.1 RefSeqGene

      Range
      6342..9327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1218

    mRNA and Protein(s)

    1. NM_001111034.3NP_001104504.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104504.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BP367008
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    2. NM_001111035.3NP_001104505.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104505.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BC111014, BP334409
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Related
      ENSP00000218758.4, ENST00000218758.9
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    3. NM_001111036.3NP_001104506.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104506.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BX365007
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Related
      ENSP00000392374.1, ENST00000412435.6
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    4. NM_001322023.2NP_001308952.1  tartrate-resistant acid phosphatase type 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC020947, BC025414, BP334409
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    5. NM_001611.5NP_001602.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001602.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AK290717, BC025414
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Related
      ENSP00000496973.1, ENST00000648477.1
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      11574660..11578983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528069.2XP_011526371.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_011526371.1

      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    2. XM_005259938.1XP_005259995.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_005259995.1

      UniProtKB/Swiss-Prot
      P13686
      UniProtKB/TrEMBL
      A0A024R7F8
      Conserved Domains (1) summary
      cd07378
      Location:26311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
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