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    Sart3 squamous cell carcinoma antigen recognized by T cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 53890, updated on 4-Jul-2021

    Summary

    Official Symbol
    Sart3provided by MGI
    Official Full Name
    squamous cell carcinoma antigen recognized by T cells 3provided by MGI
    Primary source
    MGI:MGI:1858230
    See related
    Ensembl:ENSMUSG00000018974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU045857; mKIAA0156
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.4), CNS E14 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sart3 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113880505..113910461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113742444..113772400, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114192455..114221658, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene FIC domain containing Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U6atac snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U6atac snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3
    Names
    SART-3
    mSART-3
    tumor-rejection antigen SART3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356621.1NP_001343550.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132939
      Conserved Domains (4) summary
      cd12391
      Location:723796
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:817897
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:895953
      LSM_int_assoc; LSM-interacting associated unstructured
      cl26993
      Location:101479
      Suf; Suppressor of forked protein (Suf)
    2. NM_001356623.1NP_001343552.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC132939
      Conserved Domains (3) summary
      cd12391
      Location:316389
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:410490
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cl25617
      Location:488546
      LSM_int_assoc; LSM-interacting associated unstructured
    3. NM_016926.2NP_058622.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

      See identical proteins and their annotated locations for NP_058622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132939, AK086398
      Consensus CDS
      CCDS19552.1
      UniProtKB/Swiss-Prot
      Q9JLI8
      Related
      ENSMUSP00000019118.4, ENSMUST00000019118.8
      Conserved Domains (7) summary
      COG0724
      Location:641858
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:101461
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:705778
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:799879
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:944961
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:334487
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:877935
      LSM_int_assoc; LSM-interacting associated unstructured

    RNA

    1. NR_151532.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has several differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132939
      Related
      ENSMUST00000197041.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113880505..113910461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254699.1XP_030110559.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

      Conserved Domains (5) summary
      COG5107
      Location:1323
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:567640
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:661741
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:806823
      Lsm_interact; Lsm interaction motif
      pfam16605
      Location:739797
      LSM_int_assoc; LSM-interacting associated unstructured
    2. XM_006530406.1XP_006530469.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      Conserved Domains (5) summary
      COG5107
      Location:1341
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:585658
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:679759
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:824841
      Lsm_interact; Lsm interaction motif
      pfam16605
      Location:757815
      LSM_int_assoc; LSM-interacting associated unstructured
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