Format

Send to:

Choose Destination
    • Showing Current items.

    Sart3 squamous cell carcinoma antigen recognized by T cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 53890, updated on 9-Sep-2018

    Summary

    Official Symbol
    Sart3provided by MGI
    Official Full Name
    squamous cell carcinoma antigen recognized by T cells 3provided by MGI
    Primary source
    MGI:MGI:1858230
    See related
    Ensembl:ENSMUSG00000018974 Vega:OTTMUSG00000054497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU045857; mKIAA0156
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.4), CNS E14 (RPKM 11.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sart3 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (113742444..113772505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114192455..114221658, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene FIC domain containing Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    U6atac snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with U6atac snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3
    Names
    SART-3
    mSART-3
    tumor-rejection antigen SART3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356621.1NP_001343550.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132939
      Conserved Domains (4) summary
      cd12391
      Location:723796
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:817897
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:895953
      LSM_int_assoc; LSM-interacting associated unstructured
      cl26993
      Location:101479
      Suf; Suppressor of forked protein (Suf)
    2. NM_001356623.1NP_001343552.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC132939
      Conserved Domains (3) summary
      cd12391
      Location:316389
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:410490
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cl25617
      Location:488546
      LSM_int_assoc; LSM-interacting associated unstructured
    3. NM_016926.2NP_058622.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

      See identical proteins and their annotated locations for NP_058622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132939, AK086398
      Consensus CDS
      CCDS19552.1
      UniProtKB/Swiss-Prot
      Q9JLI8
      Related
      ENSMUSP00000019118.3, OTTMUSP00000071570, ENSMUST00000019118.7
      Conserved Domains (7) summary
      COG0724
      Location:641858
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:101461
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:705778
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:799879
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:944961
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:334487
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:877935
      LSM_int_assoc; LSM-interacting associated unstructured

    RNA

    1. NR_151532.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has several differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132939

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      113742444..113772505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320991.1XP_017176480.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X3

      Conserved Domains (3) summary
      cd12391
      Location:316389
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:410490
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cl25617
      Location:488546
      LSM_int_assoc; LSM-interacting associated unstructured
    2. XM_006530405.1XP_006530468.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      Conserved Domains (4) summary
      cd12391
      Location:723796
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:817897
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:895953
      LSM_int_assoc; LSM-interacting associated unstructured
      cl26993
      Location:101479
      Suf; Suppressor of forked protein (Suf)
    3. XM_006530406.1XP_006530469.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

      Conserved Domains (7) summary
      COG0724
      Location:521738
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:1341
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:585658
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:679759
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:824841
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:214367
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:757815
      LSM_int_assoc; LSM-interacting associated unstructured
    Support Center