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    Cdkl2 cyclin-dependent kinase-like 2 (CDC2-related kinase) [ Mus musculus (house mouse) ]

    Gene ID: 53886, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdkl2provided by MGI
    Official Full Name
    cyclin-dependent kinase-like 2 (CDC2-related kinase)provided by MGI
    Primary source
    MGI:MGI:1858227
    See related
    Ensembl:ENSMUSG00000029403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kkm; KKIAMRE; AI505225; 5330436L21Rik
    Expression
    Biased expression in testis adult (RPKM 6.7), CNS E18 (RPKM 3.6) and 14 other tissues See more
    Orthologs

    Genomic context

    See Cdkl2 in Genome Data Viewer
    Location:
    5; 5 E2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (92006074..92043042, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (92435101..92472044, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ring finger and CHY zinc finger domain containing 1 Neighboring gene THAP domain containing 6 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene predicted gene, 46915 Neighboring gene GTPase activating protein (SH3 domain) binding protein 2 Neighboring gene predicted gene, 42111 Neighboring gene predicted gene, 46933

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC144031, MGC144032

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase-like 2
    NP_001263244.1
    NP_058608.1
    NP_796244.2
    XP_011247839.1
    XP_011247840.1
    XP_011247841.1
    XP_017176476.1
    XP_017176477.1
    XP_017176478.1
    XP_017176479.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276315.1NP_001263244.1  cyclin-dependent kinase-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001263244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB029066, AK030598, AK139820, BB616412, CD348339
      Consensus CDS
      CCDS19425.1
      UniProtKB/Swiss-Prot
      Q9QUK0
      Related
      ENSMUSP00000108768.1, ENSMUST00000113143.7
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    2. NM_016912.2NP_058608.1  cyclin-dependent kinase-like 2 isoform 1

      See identical proteins and their annotated locations for NP_058608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as beta).
      Source sequence(s)
      AB029065, AB029066, AC165433, CD348339, CJ047658
      Consensus CDS
      CCDS19426.1
      UniProtKB/Swiss-Prot
      Q9QUK0
      UniProtKB/TrEMBL
      Q149A0
      Related
      ENSMUSP00000084199.5, ENSMUST00000086978.11
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    3. NM_177270.4NP_796244.2  cyclin-dependent kinase-like 2 isoform 2

      See identical proteins and their annotated locations for NP_796244.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB029066, AC165433, CD348339, CJ047658
      Consensus CDS
      CCDS19425.1
      UniProtKB/Swiss-Prot
      Q9QUK0
      Related
      ENSMUSP00000063617.4, ENSMUST00000069937.10
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      92006074..92043042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320989.1XP_017176478.1  cyclin-dependent kinase-like 2 isoform X4

    2. XM_017320987.1XP_017176476.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QUK0
      UniProtKB/TrEMBL
      Q149A0
      Related
      ENSMUSP00000108765.1, ENSMUST00000113140.4
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    3. XM_017320988.1XP_017176477.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QUK0
      UniProtKB/TrEMBL
      Q149A0
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    4. XM_011249538.2XP_011247840.1  cyclin-dependent kinase-like 2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    5. XM_011249537.2XP_011247839.1  cyclin-dependent kinase-like 2 isoform X1

      See identical proteins and their annotated locations for XP_011247839.1

      UniProtKB/Swiss-Prot
      Q9QUK0
      UniProtKB/TrEMBL
      Q149A0
      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    6. XM_011249539.2XP_011247841.1  cyclin-dependent kinase-like 2 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    7. XM_017320990.1XP_017176479.1  cyclin-dependent kinase-like 2 isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:4289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
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