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    Caprin1 cell cycle associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 53872, updated on 31-Jan-2019

    Summary

    Official Symbol
    Caprin1provided by MGI
    Official Full Name
    cell cycle associated protein 1provided by MGI
    Primary source
    MGI:MGI:1858234
    See related
    Ensembl:ENSMUSG00000027184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P137; Gpiap; Gpiap1; rng105; AL022980; Caprin-1; Mmgpip137
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.6), whole brain E14.5 (RPKM 41.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Caprin1 in Genome Data Viewer
    Location:
    2; 2 E2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (103762945..103797640, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (103603102..103637797, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene ankyrin repeat and BTB (POZ) domain containing 2 Neighboring gene N-acetyltransferase 10 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene, 39894 Neighboring gene predicted gene 13880

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caprin-1
    Names
    GPI-anchored membrane protein 1
    GPI-anchored protein p137
    GPI-p137
    RNA granule protein 105
    cytoplasmic activation- and proliferation-associated protein 1
    cytoplasmic activation/proliferation-associated protein 1
    membrane component chromosome 11 surface marker 1
    p137GPI

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111289.1NP_001104759.1  caprin-1 isoform a

      See identical proteins and their annotated locations for NP_001104759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK141992, AK168676, BK001105, BP757172, BX537331, CJ060786
      Consensus CDS
      CCDS16481.1
      UniProtKB/Swiss-Prot
      Q60865
      Related
      ENSMUSP00000106777.1, ENSMUST00000111147.7
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    2. NM_001111290.1NP_001104760.1  caprin-1 isoform b

      See identical proteins and their annotated locations for NP_001104760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK168676, BK001105, BP757172, BX537331, CJ060786
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (1) summary
      pfam12287
      Location:365668
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    3. NM_001111291.1NP_001104761.1  caprin-1 isoform c

      See identical proteins and their annotated locations for NP_001104761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AK133891, AK166461, BB836551, BK001105, BX513935, CJ045742
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    4. NM_001111292.1NP_001104762.1  caprin-1 isoform c

      See identical proteins and their annotated locations for NP_001104762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AK166461, AK168676, BB836551, BK001105, BX513935, CJ060786
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    5. NM_016739.3NP_058019.2  caprin-1 isoform a

      See identical proteins and their annotated locations for NP_058019.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BK001105, BP757172, BX537331, CJ045742
      Consensus CDS
      CCDS16481.1
      UniProtKB/Swiss-Prot
      Q60865
      Related
      ENSMUSP00000028607.6, ENSMUST00000028607.12
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      103762945..103797640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499902.2XP_006499965.1  caprin-1 isoform X1

      Conserved Domains (1) summary
      pfam12287
      Location:286598
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
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