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    Pkd2l2 polycystic kidney disease 2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 53871, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pkd2l2provided by MGI
    Official Full Name
    polycystic kidney disease 2-like 2provided by MGI
    Primary source
    MGI:MGI:1858231
    See related
    Ensembl:ENSMUSG00000014503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR; TRPP5
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), CNS E18 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pkd2l2 in Genome Data Viewer
    Location:
    18; 18 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34541553..34575842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34408501..34442798)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34569077..34602443)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene SET translocation pseudogene Neighboring gene family with sequence similarity 13, member B Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene NME/NM23 family member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    polycystic kidney disease 2-like 2 protein
    Names
    Polycystin - L2
    polycystin-2L2
    polycystin-L2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163004.1NP_001156476.1  polycystic kidney disease 2-like 2 protein

      See identical proteins and their annotated locations for NP_001156476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AK133423, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      Q9JLG4
      UniProtKB/TrEMBL
      Q3V056
      Related
      ENSMUSP00000127257.2, ENSMUST00000166156.9
      Conserved Domains (1) summary
      pfam08016
      Location:76497
      PKD_channel; Polycystin cation channel
    2. NM_016927.3NP_058623.2  polycystic kidney disease 2-like 2 protein

      See identical proteins and their annotated locations for NP_058623.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AC115305, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      Q9JLG4
      Related
      ENSMUSP00000014647.8, ENSMUST00000014647.9
      Conserved Domains (1) summary
      pfam08016
      Location:76497
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34541553..34575842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317946.3XP_017173435.1  polycystic kidney disease 2-like 2 protein isoform X3

      Conserved Domains (1) summary
      pfam08016
      Location:28449
      PKD_channel; Polycystin cation channel
    2. XM_017317949.3XP_017173438.1  polycystic kidney disease 2-like 2 protein isoform X6

      Conserved Domains (1) summary
      pfam08016
      Location:1407
      PKD_channel; Polycystin cation channel
    3. XM_017317950.3XP_017173439.1  polycystic kidney disease 2-like 2 protein isoform X6

      Conserved Domains (1) summary
      pfam08016
      Location:1407
      PKD_channel; Polycystin cation channel
    4. XM_017317944.3XP_017173433.1  polycystic kidney disease 2-like 2 protein isoform X1

      Conserved Domains (1) summary
      pfam08016
      Location:78499
      PKD_channel; Polycystin cation channel
    5. XM_017317948.3XP_017173437.1  polycystic kidney disease 2-like 2 protein isoform X5

      Conserved Domains (1) summary
      pfam08016
      Location:78442
      PKD_channel; Polycystin cation channel
    6. XM_036161210.1XP_036017103.1  polycystic kidney disease 2-like 2 protein isoform X2

      Conserved Domains (1) summary
      pfam08016
      Location:43463
      PKD_channel; Polycystin cation channel
    7. XM_017317947.3XP_017173436.1  polycystic kidney disease 2-like 2 protein isoform X3

      Conserved Domains (1) summary
      pfam08016
      Location:28449
      PKD_channel; Polycystin cation channel
    8. XM_006526097.5XP_006526160.1  polycystic kidney disease 2-like 2 protein isoform X4

      Conserved Domains (1) summary
      pfam08016
      Location:78499
      PKD_channel; Polycystin cation channel
    9. XM_036161212.1XP_036017105.1  polycystic kidney disease 2-like 2 protein isoform X7

      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    10. XM_017317951.3XP_017173440.1  polycystic kidney disease 2-like 2 protein isoform X7

      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    11. XM_006526101.5XP_006526164.1  polycystic kidney disease 2-like 2 protein isoform X7

      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    12. XM_006526104.4XP_006526167.1  polycystic kidney disease 2-like 2 protein isoform X8

      Conserved Domains (1) summary
      pfam08016
      Location:78281
      PKD_channel; Polycystin cation channel
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