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    Cnot4 CCR4-NOT transcription complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 53621, updated on 2-Oct-2018

    Summary

    Official Symbol
    Cnot4provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1859026
    See related
    Ensembl:ENSMUSG00000038784 Vega:OTTMUSG00000056105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Not4; Not4h; Not4hp
    Expression
    Ubiquitous expression in testis adult (RPKM 3.6), cerebellum adult (RPKM 1.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cnot4 in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (35022065..35133737, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (34972065..35083737, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene stimulated by retinoic acid gene 8 Neighboring gene solute carrier family 23 member 4 Neighboring gene predicted gene, 33046 Neighboring gene nucleoporin 205 Neighboring gene RIKEN cDNA 1810058I24 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 4
    Names
    CCR4-associated factor 4
    E3 ubiquitin-protein ligase CNOT4
    RING-type E3 ubiquitin transferase CNOT4
    negative regulator of transcription 4
    potential transcriptional repressor NOT4Hp
    transcriptional repressor NOT4Hp
    NP_001157883.1
    NP_001157884.1
    NP_001157885.1
    NP_001157886.1
    NP_058573.3
    XP_011239709.1
    XP_011239710.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164411.1NP_001157883.1  CCR4-NOT transcription complex subunit 4 isoform 3

      See identical proteins and their annotated locations for NP_001157883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110, AK028190, AK075887, AW125319
      Consensus CDS
      CCDS80520.1
      UniProtKB/Swiss-Prot
      Q8BT14
      UniProtKB/TrEMBL
      Q3TMD4
      Related
      ENSMUSP00000144409.1, OTTMUSP00000072906, ENSMUST00000202417.1, OTTMUST00000138745
      Conserved Domains (3) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    2. NM_001164412.1NP_001157884.1  CCR4-NOT transcription complex subunit 4 isoform 4

      See identical proteins and their annotated locations for NP_001157884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC140110, BC048243
      Consensus CDS
      CCDS80519.1
      UniProtKB/TrEMBL
      Q05BG1
      Related
      ENSMUSP00000144352.1, OTTMUSP00000072902, ENSMUST00000202143.3, OTTMUST00000138740
      Conserved Domains (3) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    3. NM_001164413.1NP_001157885.1  CCR4-NOT transcription complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001157885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC140110, BC048243
      Consensus CDS
      CCDS51747.1
      UniProtKB/Swiss-Prot
      Q8BT14
      UniProtKB/TrEMBL
      A0A0R4J1K1, Q05BG1
      Related
      ENSMUSP00000110645.2, OTTMUSP00000072904, ENSMUST00000114993.8, OTTMUST00000138742
      Conserved Domains (3) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    4. NM_001164414.1NP_001157886.1  CCR4-NOT transcription complex subunit 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC140110, BC048243
      Consensus CDS
      CCDS51746.1
      UniProtKB/TrEMBL
      E9QA19, Q05BG1
      Related
      ENSMUSP00000110640.2, OTTMUSP00000072903, ENSMUST00000114989.8, OTTMUST00000138741
      Conserved Domains (3) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    5. NM_016877.4NP_058573.3  CCR4-NOT transcription complex subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_058573.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110, AK032248, AW125319
      Consensus CDS
      CCDS19999.1
      UniProtKB/Swiss-Prot
      Q8BT14
      Related
      ENSMUSP00000044137.6, OTTMUSP00000072905, ENSMUST00000044163.9, OTTMUST00000138744
      Conserved Domains (3) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      35022065..35133737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241407.1XP_011239709.1  CCR4-NOT transcription complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_011239709.1

      UniProtKB/Swiss-Prot
      Q8BT14
      Conserved Domains (3) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    2. XM_011241408.2XP_011239710.1  CCR4-NOT transcription complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_011239710.1

      UniProtKB/Swiss-Prot
      Q8BT14
      Conserved Domains (3) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain

    RNA

    1. XR_001785152.1 RNA Sequence

    2. XR_001785150.1 RNA Sequence

    3. XR_001785153.1 RNA Sequence

    4. XR_001785151.1 RNA Sequence

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