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    Cnot4 CCR4-NOT transcription complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 53621, updated on 26-Sep-2022

    Summary

    Official Symbol
    Cnot4provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1859026
    See related
    Ensembl:ENSMUSG00000038784 AllianceGenome:MGI:1859026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Not4; Not4h; Not4hp
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; regulation of megakaryocyte differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including central nervous system; genitourinary system; and neural retina. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.6), cerebellum adult (RPKM 1.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cnot4 in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34999000..35110692, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (35022065..35133754, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene stimulated by retinoic acid gene 8 Neighboring gene solute carrier family 23 member 4 Neighboring gene predicted gene, 33046 Neighboring gene nucleoporin 205 Neighboring gene RIKEN cDNA 1810058I24 gene Neighboring gene predicted gene, 23435

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 4
    Names
    CCR4-associated factor 4
    E3 ubiquitin-protein ligase CNOT4
    RING-type E3 ubiquitin transferase CNOT4
    negative regulator of transcription 4
    potential transcriptional repressor NOT4Hp
    transcriptional repressor NOT4Hp
    NP_001157883.1
    NP_001157884.1
    NP_001157885.1
    NP_001157886.1
    NP_058573.3
    XP_011239709.1
    XP_011239710.1
    XP_036022174.1
    XP_036022175.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164411.2NP_001157883.1  CCR4-NOT transcription complex subunit 4 isoform 3

      See identical proteins and their annotated locations for NP_001157883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS80520.1
      UniProtKB/Swiss-Prot
      Q8BT14
      UniProtKB/TrEMBL
      Q3TMD4
      Related
      ENSMUSP00000144409.2, ENSMUST00000202417.2
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
    2. NM_001164412.2NP_001157884.1  CCR4-NOT transcription complex subunit 4 isoform 4

      See identical proteins and their annotated locations for NP_001157884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS80519.1
      UniProtKB/TrEMBL
      Q05BG1
      Related
      ENSMUSP00000144352.2, ENSMUST00000202143.4
      Conserved Domains (3) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    3. NM_001164413.2NP_001157885.1  CCR4-NOT transcription complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001157885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS51747.1
      UniProtKB/Swiss-Prot
      Q8BT14
      UniProtKB/TrEMBL
      A0A0R4J1K1, Q05BG1
      Related
      ENSMUSP00000110645.3, ENSMUST00000114993.9
      Conserved Domains (3) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    4. NM_001164414.2NP_001157886.1  CCR4-NOT transcription complex subunit 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS51746.1
      UniProtKB/TrEMBL
      E9QA19, Q05BG1
      Related
      ENSMUSP00000110640.3, ENSMUST00000114989.9
      Conserved Domains (3) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:1460
      zf-RING_4; RING/Ubox like zinc-binding domain
    5. NM_001410682.1NP_001397611.1  CCR4-NOT transcription complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140110
    6. NM_001410683.1NP_001397612.1  CCR4-NOT transcription complex subunit 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140110
    7. NM_001410684.1NP_001397613.1  CCR4-NOT transcription complex subunit 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140110
    8. NM_001410685.1NP_001397614.1  CCR4-NOT transcription complex subunit 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140110
    9. NM_001410686.1NP_001397615.1  CCR4-NOT transcription complex subunit 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC140110
    10. NM_016877.5NP_058573.3  CCR4-NOT transcription complex subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_058573.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS19999.1
      UniProtKB/Swiss-Prot
      Q8BT14, Q9Z1D0
      Related
      ENSMUSP00000044137.7, ENSMUST00000044163.10
      Conserved Domains (2) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      pfam08580
      Location:273478
      KAR9; Yeast cortical protein KAR9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34999000..35110692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241407.3XP_011239709.1  CCR4-NOT transcription complex subunit 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8BT14
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    2. XM_011241408.3XP_011239710.1  CCR4-NOT transcription complex subunit 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8BT14
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    3. XM_036166282.1XP_036022175.1  CCR4-NOT transcription complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      Q3TMD4
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
    4. XM_036166281.1XP_036022174.1  CCR4-NOT transcription complex subunit 4 isoform X2

      UniProtKB/Swiss-Prot
      Q9Z1D0
      Conserved Domains (2) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
      pfam08580
      Location:273478
      KAR9; Yeast cortical protein KAR9