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    Blcap bladder cancer associated protein [ Mus musculus (house mouse) ]

    Gene ID: 53619, updated on 6-Jan-2026
    Official Symbol
    Blcapprovided by MGI
    Official Full Name
    bladder cancer associated proteinprovided by MGI
    Primary source
    MGI:MGI:1858907
    See related
    Ensembl:ENSMUSG00000067787 AllianceGenome:MGI:1858907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bc10
    Summary
    Predicted to be involved in apoptotic nuclear changes. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in brain and spinal cord. Orthologous to human BLCAP (BLCAP apoptosis inducing factor). [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 60.0), CNS E18 (RPKM 57.7) and 28 other tissues See more
    Orthologs
    human all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See Blcap in Genome Data Viewer
    Location:
    2 H1; 2 78.4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157398282..157408281, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157556362..157566361, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene src proto-oncogene, non-receptor tyrosine kinase Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157392020-157392207 Neighboring gene neuronatin Neighboring gene STARR-seq mESC enhancer starr_06215 Neighboring gene pluripotency associated transcript 27 Neighboring gene STARR-seq mESC enhancer starr_06217 Neighboring gene predicted gene, 34293

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Related articles in PubMed

    1. The 3D Genome Structure of a Blcap-Linked Silencer Loop Regulates Terminal Differentiation During Lens Fiber Cell Denucleation. Ke S, et al. Invest Ophthalmol Vis Sci, 2025 Dec 1. PMID 41358657, Free PMC Article
    2. Transcript- and tissue-specific imprinting of a tumour suppressor gene. Schulz R, et al. Hum Mol Genet, 2009 Jan 1. PMID 18836209, Free PMC Article
    3. Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. John RM, et al. Dev Biol, 2001 Aug 15. PMID 11476579
    4. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, et al. J Biol Chem, 2002 Feb 22. PMID 11741941
    5. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blcap is imprinted in mouse and human brain, but not in other mouse tissues.
      Title: Transcript- and tissue-specific imprinting of a tumour suppressor gene.
    Submit: New GeneRIF Correction

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Markers

    Homology

    Clone Names

    • MGC102074

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic nuclear changes IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic nuclear changes ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    apoptosis inducing factor BLCAP
    Names
    BLCAP apoptosis inducing factor
    Blcapbladder cancer associated protein homolog
    bladder cancer 10 kDa protein
    bladder cancer associated protein homolog
    bladder cancer related protein

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355426.1 → NP_001342355.1  apoptosis inducing factor BLCAP

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL672259
      Consensus CDS
      CCDS16979.1
      UniProtKB/Swiss-Prot
      A2AFZ4, P62951, Q3TD76, Q5XJG3
      Related
      ENSMUSP00000085849.3, ENSMUST00000088494.3
      Conserved Domains (1) summary
      pfam06726
      Location:1 → 65
      BC10; Bladder cancer-related protein BC10

    2. NM_016916.3 → NP_058612.3  apoptosis inducing factor BLCAP

      See identical proteins and their annotated locations for NP_058612.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC083339, BM950751, BY718283
      Consensus CDS
      CCDS16979.1
      UniProtKB/Swiss-Prot
      A2AFZ4, P62951, Q3TD76, Q5XJG3
      Related
      ENSMUSP00000105154.3, ENSMUST00000109528.9
      Conserved Domains (1) summary
      pfam06726
      Location:1 → 65
      BC10; Bladder cancer-related protein BC10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157398282..157408281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62951.1 GenPept UniProtKB/Swiss-Prot:P62951

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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