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    Snrpa small nuclear ribonucleoprotein polypeptide A [ Mus musculus (house mouse) ]

    Gene ID: 53607, updated on 5-Aug-2018

    Summary

    Official Symbol
    Snrpaprovided by MGI
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Aprovided by MGI
    Primary source
    MGI:MGI:1855690
    See related
    Ensembl:ENSMUSG00000061479 Vega:OTTMUSG00000031830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U1A; U1-A; Rnu1a1; Rnu1a-1; C430021M15Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 95.1), limb E14.5 (RPKM 88.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Snrpa in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (27187006..27196271, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27972025..27981290, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RAB4B, member RAS oncogene family Neighboring gene microRNA 3101 Neighboring gene melanoma inhibitory activity Neighboring gene cDNA sequence BC024978 Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U1-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U1-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, U1-snRNP, conserved biosystem (from KEGG)
      Spliceosome, U1-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    snRNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    U1 small nuclear ribonucleoprotein A
    Names
    U1 snRNP A
    protein A of the U1 small nuclear RNA

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046637.1NP_001040102.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_001040102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC157561, AI851424, AW541778, CX565356
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q62189
      Related
      ENSMUSP00000131897.2, ENSMUST00000163311.8
      Conserved Domains (3) summary
      COG0724
      Location:7122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)
    2. NM_001285825.1NP_001272754.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_001272754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI851424, CA552113, CX206945, DV650448
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q62189
      Related
      ENSMUSP00000113678.1, OTTMUSP00000042024, ENSMUST00000122202.7, OTTMUST00000078920
      Conserved Domains (3) summary
      COG0724
      Location:7122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)
    3. NM_015782.3NP_056597.3  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_056597.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI851424, BC096648, CX206945
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q62189
      Related
      ENSMUSP00000079228.3, OTTMUSP00000042023, ENSMUST00000080356.9, OTTMUST00000078919
      Conserved Domains (3) summary
      COG0724
      Location:7122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      27187006..27196271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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