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    CG3021 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53546, updated on 24-Nov-2022

    Summary

    Official Symbol
    CG3021provided by FlyBase
    Primary source
    FLYBASE:FBgn0040337
    Locus tag
    Dmel_CG3021
    See related
    AllianceGenome:FB:FBgn0040337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-1Ed; Dmel\CG3021; E; EG:BACR7A4.8
    Summary
    Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See CG3021 in Genome Data Viewer
    Location:
    1E1-1E1; 1-0.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1026791..1028290)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (920824..922323)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 45 Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p21

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the CG3021 gene: The CG3021 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG3021-PA
    transcription unit E
    NP_652639.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1026791..1028290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144382.4NP_652639.1  uncharacterized protein Dmel_CG3021 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960Y5, Q9W5B6
      Related
      FBpp0070168, FBtr0070173
      Conserved Domains (2) summary
      cd01998
      Location:14366
      tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
      pfam03054
      Location:14366
      tRNA_Me_trans; tRNA methyl transferase