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    Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Mus musculus (house mouse) ]

    Gene ID: 53379, updated on 18-Sep-2024

    Summary

    Official Symbol
    Hnrnpa2b1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by MGI
    Primary source
    MGI:MGI:104819
    See related
    Ensembl:ENSMUSG00000004980 AllianceGenome:MGI:104819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik
    Summary
    Enables pre-mRNA intronic binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 290.0), liver E14 (RPKM 181.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hnrnpa2b1 in Genome Data Viewer
    Location:
    6 B3; 6 24.87 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51437414..51448054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51460434..51470048, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:51333989-51334289 Neighboring gene predicted gene 6559 Neighboring gene STARR-seq mESC enhancer starr_15870 Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene chromobox 3 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene sorting nexin 10 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in miRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    heterogenous nuclear ribonucleoprotein A2/B1
    hnRNP A2/B1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374745.1NP_001361674.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC154011
      Consensus CDS
      CCDS90046.1
      UniProtKB/Swiss-Prot
      B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
      UniProtKB/TrEMBL
      B7ZP22
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. NM_016806.3NP_058086.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1

      See identical proteins and their annotated locations for NP_058086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253, CN665325
      Consensus CDS
      CCDS51774.1
      UniProtKB/TrEMBL
      B7ZP22
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    3. NM_182650.4NP_872591.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

      See identical proteins and their annotated locations for NP_872591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK035626, AK137214, BC141253
      Consensus CDS
      CCDS51773.1
      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000067491.7, ENSMUST00000069949.13
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RNA

    1. NR_104468.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      51437414..51448054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166280.1XP_036022173.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000145383.2, ENSMUST00000204158.3
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. XM_030255496.2XP_030111356.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000087453.8, ENSMUST00000090002.10
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    3. XM_006506373.5XP_006506436.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_006506436.2

      UniProtKB/Swiss-Prot
      B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000145028.2, ENSMUST00000203954.3
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    4. XM_030255499.2XP_030111359.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      UniProtKB/TrEMBL
      B7ZP22
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1
    5. XM_030255500.2XP_030111360.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000145245.2, ENSMUST00000204188.3
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    6. XM_036166279.1XP_036022172.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000145374.2, ENSMUST00000203220.3
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    7. XM_036166278.1XP_036022171.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      UniProtKB/Swiss-Prot
      B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
      UniProtKB/TrEMBL
      B7ZP22
      Related
      ENSMUSP00000110103.3, ENSMUST00000114459.8
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    8. XM_030255497.2XP_030111357.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      UniProtKB/TrEMBL
      B7ZP22
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1
    9. XM_030255498.2XP_030111358.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      UniProtKB/TrEMBL
      B7ZP22
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1

    RNA

    1. XR_377482.5 RNA Sequence

    2. XR_003956232.2 RNA Sequence

    3. XR_003956229.2 RNA Sequence

    4. XR_003956228.1 RNA Sequence

    5. XR_377483.5 RNA Sequence

    6. XR_003956231.2 RNA Sequence

    7. XR_003956230.2 RNA Sequence

    8. XR_004942983.1 RNA Sequence

    9. XR_868868.3 RNA Sequence

    10. XR_004942981.1 RNA Sequence

    11. XR_868866.3 RNA Sequence

    12. XR_868865.3 RNA Sequence

    13. XR_868864.3 RNA Sequence

    14. XR_004942982.1 RNA Sequence