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    Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Mus musculus (house mouse) ]

    Gene ID: 53379, updated on 7-Apr-2019

    Summary

    Official Symbol
    Hnrnpa2b1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by MGI
    Primary source
    MGI:MGI:104819
    See related
    Ensembl:ENSMUSG00000004980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 290.0), liver E14 (RPKM 181.3) and 16 other tissues See more
    Orthologs

    Genomic context

    See Hnrnpa2b1 in Genome Data Viewer
    Location:
    6; 6 B3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (51460434..51470315, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (51410433..51419893, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6559 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene chromobox 3 Neighboring gene sorting nexin 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    N6-methyladenosine-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    RNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of telomerase RNA reverse transcriptase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    heterogenous nuclear ribonucleoprotein A2/B1
    hnRNP A2/B1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016806.3NP_058086.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1

      See identical proteins and their annotated locations for NP_058086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253, CN665325
      Consensus CDS
      CCDS51774.1
      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000087453.7, ENSMUST00000090002.9
      Conserved Domains (3) summary
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:290311
      HnRNPA1; Nuclear factor hnRNPA1
    2. NM_182650.4NP_872591.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

      See identical proteins and their annotated locations for NP_872591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK035626, AK137214, BC141253
      Consensus CDS
      CCDS51773.1
      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000067491.6, ENSMUST00000069949.12
      Conserved Domains (3) summary
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:247275
      HnRNPA1; Nuclear factor hnRNPA1

    RNA

    1. NR_104468.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      51460434..51470315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506374.3XP_006506437.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_006506437.2

      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000145028.1, ENSMUST00000203954.2
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:302323
      HnRNPA1; Nuclear factor hnRNPA1
    2. XM_006506373.3XP_006506436.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_006506436.2

      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000110103.2, ENSMUST00000114459.7
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:302323
      HnRNPA1; Nuclear factor hnRNPA1

    RNA

    1. XR_377483.3 RNA Sequence

    2. XR_377482.3 RNA Sequence

    3. XR_868869.2 RNA Sequence

    4. XR_868866.2 RNA Sequence

    5. XR_868865.2 RNA Sequence

    6. XR_868864.2 RNA Sequence

    7. XR_868870.2 RNA Sequence

    8. XR_868868.2 RNA Sequence

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