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    Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Mus musculus (house mouse) ]

    Gene ID: 53379, updated on 5-Sep-2021

    Summary

    Official Symbol
    Hnrnpa2b1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by MGI
    Primary source
    MGI:MGI:104819
    See related
    Ensembl:ENSMUSG00000004980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hn; Hnrp; Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 290.0), liver E14 (RPKM 181.3) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hnrnpa2b1 in Genome Data Viewer
    Location:
    6; 6 B3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51437414..51448054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51460434..51470048, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (51410433..51419893, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6559 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene chromobox 3 Neighboring gene sorting nexin 10 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of telomerase RNA reverse transcriptase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    heterogenous nuclear ribonucleoprotein A2/B1
    hnRNP A2/B1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374745.1NP_001361674.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC154011
      Consensus CDS
      CCDS90046.1
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. NM_016806.3NP_058086.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1

      See identical proteins and their annotated locations for NP_058086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253, CN665325
      Consensus CDS
      CCDS51774.1
      UniProtKB/Swiss-Prot
      O88569
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    3. NM_182650.4NP_872591.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

      See identical proteins and their annotated locations for NP_872591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK035626, AK137214, BC141253
      Consensus CDS
      CCDS51773.1
      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000067491.7, ENSMUST00000069949.13
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RNA

    1. NR_104468.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK035626, AK137214, BB627924, BC141253

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      51437414..51448054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166280.1XP_036022173.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      Related
      ENSMUSP00000145383.2, ENSMUST00000204158.3
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. XM_030255496.2XP_030111356.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      Related
      ENSMUSP00000087453.8, ENSMUST00000090002.10
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    3. XM_006506373.5XP_006506436.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_006506436.2

      UniProtKB/Swiss-Prot
      O88569
      Related
      ENSMUSP00000145028.2, ENSMUST00000203954.3
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    4. XM_030255499.2XP_030111359.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1
    5. XM_030255500.2XP_030111360.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

      Related
      ENSMUSP00000145245.2, ENSMUST00000204188.3
      Conserved Domains (3) summary
      pfam11627
      Location:247274
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    6. XM_036166279.1XP_036022172.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      Related
      ENSMUSP00000145374.2, ENSMUST00000203220.3
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    7. XM_036166278.1XP_036022171.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      Related
      ENSMUSP00000110103.3, ENSMUST00000114459.8
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    8. XM_030255497.2XP_030111357.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1
    9. XM_030255498.2XP_030111358.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:259283
      HnRNPA1; Nuclear factor hnRNPA1

    RNA

    1. XR_377482.5 RNA Sequence

    2. XR_003956232.2 RNA Sequence

    3. XR_003956229.2 RNA Sequence

    4. XR_003956228.1 RNA Sequence

    5. XR_377483.5 RNA Sequence

    6. XR_003956231.2 RNA Sequence

    7. XR_003956230.2 RNA Sequence

    8. XR_004942983.1 RNA Sequence

    9. XR_868868.3 RNA Sequence

    10. XR_004942981.1 RNA Sequence

    11. XR_868866.3 RNA Sequence

    12. XR_868865.3 RNA Sequence

    13. XR_868864.3 RNA Sequence

    14. XR_004942982.1 RNA Sequence

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