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    SPA17 sperm autoantigenic protein 17 [ Homo sapiens (human) ]

    Gene ID: 53340, updated on 19-Sep-2024

    Summary

    Official Symbol
    SPA17provided by HGNC
    Official Full Name
    sperm autoantigenic protein 17provided by HGNC
    Primary source
    HGNC:HGNC:11210
    See related
    Ensembl:ENSG00000064199 MIM:608621; AllianceGenome:HGNC:11210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT22; SP17; SP17-1
    Summary
    This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
    Expression
    Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPA17 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124673904..124697518)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124702562..124726178)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124543800..124567414)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5688 Neighboring gene transforming growth factor beta regulator 1 Neighboring gene RNA, 5S ribosomal pseudogene 352 Neighboring gene sialic acid acetylesterase Neighboring gene ReSE screen-validated silencer GRCh37_chr11:124543663-124543821 Neighboring gene uncharacterized LOC124902780 Neighboring gene MPRA-validated peak1498 silencer Neighboring gene uncharacterized LOC107984405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124615273-124615806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124616341-124616874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4027 Neighboring gene neurogranin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sperm surface protein Sp17
    Names
    cancer/testis antigen 22
    sperm protein 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017425.4NP_059121.1  sperm surface protein Sp17

      See identical proteins and their annotated locations for NP_059121.1

      Status: REVIEWED

      Source sequence(s)
      AF334735, AP000890
      Consensus CDS
      CCDS8450.1
      UniProtKB/Swiss-Prot
      B2R4F2, Q15506, Q9BXF7
      UniProtKB/TrEMBL
      A0A172Q397, Q05D07
      Related
      ENSP00000227135.2, ENST00000227135.7
      Conserved Domains (2) summary
      smart00015
      Location:117135
      IQ; Calmodulin-binding motif
      cd12100
      Location:1250
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      124673904..124697518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448583.2XP_024304351.1  sperm surface protein Sp17 isoform X1

      UniProtKB/Swiss-Prot
      B2R4F2, Q15506, Q9BXF7
      UniProtKB/TrEMBL
      A0A172Q397, Q05D07
      Conserved Domains (2) summary
      smart00015
      Location:117135
      IQ; Calmodulin-binding motif
      cd12100
      Location:1250
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    2. XM_011542870.3XP_011541172.1  sperm surface protein Sp17 isoform X1

      See identical proteins and their annotated locations for XP_011541172.1

      UniProtKB/Swiss-Prot
      B2R4F2, Q15506, Q9BXF7
      UniProtKB/TrEMBL
      A0A172Q397, Q05D07
      Related
      ENSP00000432305.1, ENST00000532692.1
      Conserved Domains (2) summary
      smart00015
      Location:117135
      IQ; Calmodulin-binding motif
      cd12100
      Location:1250
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      124702562..124726178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369135.1XP_054225110.1  sperm surface protein Sp17 isoform X1

      UniProtKB/Swiss-Prot
      B2R4F2, Q15506, Q9BXF7
      UniProtKB/TrEMBL
      A0A172Q397, Q05D07
    2. XM_054369134.1XP_054225109.1  sperm surface protein Sp17 isoform X1

      UniProtKB/Swiss-Prot
      B2R4F2, Q15506, Q9BXF7
      UniProtKB/TrEMBL
      A0A172Q397, Q05D07