Format

Send to:

Choose Destination
    • Showing Current items.

    Ube2k ubiquitin-conjugating enzyme E2K [ Mus musculus (house mouse) ]

    Gene ID: 53323, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2kprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Kprovided by MGI
    Primary source
    MGI:MGI:1858216
    See related
    Ensembl:ENSMUSG00000029203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hi; Lig; Hip2; Hypg; HIP-2; E2-25k; AW492011; D5Ertd601; D5Ertd601e
    Expression
    Ubiquitous expression in testis adult (RPKM 20.5), CNS E18 (RPKM 19.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ube2k in Genome Data Viewer
    Location:
    5 C3.1; 5 33.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65694588..65756332)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65537245..65598989)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (65928500..65990228)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1569 Neighboring gene UDP-glucose dehydrogenase Neighboring gene small integral membrane protein 14 Neighboring gene predicted gene, 40309 Neighboring gene PDS5 cohesin associated factor A Neighboring gene predicted gene, 24399 Neighboring gene predicted gene 5296 Neighboring gene NEDD4 binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 K
    Names
    E2 ubiquitin-conjugating enzyme K
    huntingtin interacting protein 2
    ubiquitin carrier protein
    ubiquitin-conjugating enzyme E2-25 kDa
    ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
    ubiquitin-protein ligase
    NP_001297547.1
    NP_001297548.1
    NP_058066.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310618.1NP_001297547.1  ubiquitin-conjugating enzyme E2 K isoform 2

      See identical proteins and their annotated locations for NP_001297547.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK036068, AK139564, AK149463, CF538783
      Consensus CDS
      CCDS80289.1
      UniProtKB/TrEMBL
      A0A0J9YU07, Q6ZWQ6
      Related
      ENSMUSP00000143941.2, ENSMUST00000201984.4
      Conserved Domains (2) summary
      smart00212
      Location:22103
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      cl21463
      Location:112149
      UBA_like_SF; UBA domain-like superfamily
    2. NM_001310619.1NP_001297548.1  ubiquitin-conjugating enzyme E2 K isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct, shorter N-terminus than isoform 1.
      Source sequence(s)
      AC112263, AC136513
      Conserved Domains (2) summary
      smart00212
      Location:284
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      cl21463
      Location:93130
      UBA_like_SF; UBA domain-like superfamily
    3. NM_016786.4NP_058066.2  ubiquitin-conjugating enzyme E2 K isoform 1

      See identical proteins and their annotated locations for NP_058066.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK036068, AK139564, AK149463
      Consensus CDS
      CCDS39098.1
      UniProtKB/Swiss-Prot
      P61087
      UniProtKB/TrEMBL
      Q6ZWQ6
      Related
      ENSMUSP00000122471.2, ENSMUST00000142407.8
      Conserved Domains (2) summary
      cd00195
      Location:6149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cd14390
      Location:163200
      UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

    RNA

    1. NR_144566.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC112263, AC136513
      Related
      ENSMUST00000202679.4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65694588..65756332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center