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    Nxf1 nuclear RNA export factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 53319, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nxf1provided by MGI
    Official Full Name
    nuclear RNA export factor 1provided by MGI
    Primary source
    MGI:MGI:1858330
    See related
    Ensembl:ENSMUSG00000010097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T; Mvb; Tap; Mvb1; Mex67
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 63.9), bladder adult (RPKM 56.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nxf1 in Genome Data Viewer
    Location:
    19 A; 19 5.5 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8734467..8748274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8757103..8770910)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8831593..8845400)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene syntaxin 5A Neighboring gene microRNA 6992 Neighboring gene RIKEN cDNA 1700023D09 gene Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene TATA-box binding protein associated factor 6 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear RNA export factor 1
    Names
    Mex 67 homolog
    mRNA export factor TAP
    modifier of vibrator 1
    nuclear RNA export factor 1 homolog
    tip associated protein
    tip associating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276704.1NP_001263633.1  nuclear RNA export factor 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal segment and transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK143640
      Consensus CDS
      CCDS70930.1
      UniProtKB/TrEMBL
      V9GXF3
      Related
      ENSMUSP00000139124.2, ENSMUST00000184970.9
      Conserved Domains (4) summary
      sd00035
      Location:223265
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:115197
      Tap-RNA_bind; Tap, RNA-binding
      pfam12799
      Location:290328
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:264326
      LRR_8; Leucine rich repeat
    2. NM_016813.2NP_058093.2  nuclear RNA export factor 1 isoform 1

      See identical proteins and their annotated locations for NP_058093.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC005594
      Consensus CDS
      CCDS29543.1
      UniProtKB/Swiss-Prot
      Q99JX7
      Related
      ENSMUSP00000010241.7, ENSMUST00000010241.14
      Conserved Domains (6) summary
      smart00804
      Location:555617
      TAP_C; C-terminal domain of vertebrate Tap protein
      cd00780
      Location:381537
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      sd00035
      Location:223265
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:115197
      Tap-RNA_bind; Tap, RNA-binding
      pfam12799
      Location:290328
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:264326
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8734467..8748274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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