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    Nub1 negative regulator of ubiquitin-like proteins 1 [ Mus musculus (house mouse) ]

    Gene ID: 53312, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nub1provided by MGI
    Official Full Name
    negative regulator of ubiquitin-like proteins 1provided by MGI
    Primary source
    MGI:MGI:1889001
    See related
    Ensembl:ENSMUSG00000028954 Vega:OTTMUSG00000053708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BS4; NY-REN-18; 4931404D21Rik; 6330412F12Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 36.3), lung adult (RPKM 24.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nub1 in Genome Data Viewer
    Location:
    5; 5 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (24685815..24710378)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (24191633..24216373)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene WD repeat domain 86 Neighboring gene predicted gene, 42231 Neighboring gene predicted gene, 33591 Neighboring gene crystallin, gamma N

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NEDD8 ultimate buster 1
    Names
    NY-REN-18 antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305264.1NP_001292193.1  NEDD8 ultimate buster 1 isoform 1

      See identical proteins and their annotated locations for NP_001292193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC137938, AI853857, AK086301, AK153400
      Consensus CDS
      CCDS80230.1
      UniProtKB/TrEMBL
      A0A0G2JGQ4
      Related
      ENSMUSP00000143657.1, OTTMUSP00000071028, ENSMUST00000197407.4, OTTMUST00000133737
      Conserved Domains (3) summary
      cd14291
      Location:399434
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:516551
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:457491
      UBA_like_SF; UBA domain-like superfamily
    2. NM_016736.3NP_058016.2  NEDD8 ultimate buster 1 isoform 2

      See identical proteins and their annotated locations for NP_058016.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC137938, AI853857, AK086301, AK134581
      Consensus CDS
      CCDS39030.1
      UniProtKB/Swiss-Prot
      P54729
      UniProtKB/TrEMBL
      Q3UYM1
      Related
      ENSMUSP00000070265.6, OTTMUSP00000071029, ENSMUST00000068825.7, OTTMUST00000133738
      Conserved Domains (3) summary
      cd14291
      Location:375410
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:492527
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:433467
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      24685815..24710378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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