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    PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Homo sapiens (human) ]

    Gene ID: 5291, updated on 5-May-2024

    Summary

    Official Symbol
    PIK3CBprovided by HGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:8976
    See related
    Ensembl:ENSG00000051382 MIM:602925; AllianceGenome:HGNC:8976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PI3K; PIK3C1; P110BETA; PI3KBETA
    Summary
    This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.2), kidney (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    3q22.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138652698..138834928, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (141393413..141575643, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138371540..138553770, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20604 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene peptidylprolyl isomerase A pseudogene 72 Neighboring gene NANOG hESC enhancer GRCh37_chr3:138448780-138449303 Neighboring gene Sharpr-MPRA regulatory region 1798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20606 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 39 Neighboring gene ribosomal protein L23a pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14766 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 25 Neighboring gene Sharpr-MPRA regulatory region 9070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138562234-138562975 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138581611-138582152 Neighboring gene Sharpr-MPRA regulatory region 8152 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4087 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138598027-138598906 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138598907-138599785 Neighboring gene uncharacterized LOC124906289 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14767

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
    env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
    Nef nef HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively PubMed
    nef HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes PubMed
    nef HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression PubMed
    nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
    nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
    nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
    nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
    Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
    tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
    tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
    tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
    tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
    tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
    tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
    tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
    Vpr vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
    vpr HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133043, DKFZp779K1237

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in angiogenesis involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic cleavage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial growth factor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in platelet aggregation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neutrophil apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of clathrin-dependent endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sphingosine-1-phosphate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Names
    PI3-kinase p110 subunit beta
    PI3-kinase subunit beta
    PI3K-beta
    PtdIns-3-kinase p110
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
    phosphoinositide-3-kinase, catalytic, beta polypeptide
    ptdIns-3-kinase subunit beta
    ptdIns-3-kinase subunit p110-beta
    serine/threonine protein kinase PIK3CB
    NP_001242974.1
    NP_006210.1
    XP_006713722.1
    XP_011511197.1
    XP_016862108.1
    XP_047304263.1
    XP_047304264.1
    XP_047304265.1
    XP_047304266.1
    XP_047304267.1
    XP_047304268.1
    XP_047304269.1
    XP_047304270.1
    XP_047304271.1
    XP_054202824.1
    XP_054202825.1
    XP_054202826.1
    XP_054202827.1
    XP_054202828.1
    XP_054202829.1
    XP_054202830.1
    XP_054202831.1
    XP_054202832.1
    XP_054202833.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256045.2NP_001242974.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC020890, AC117389, AI623206, AK293754
      UniProtKB/TrEMBL
      B4DER4
      Related
      ENSP00000438259.1, ENST00000544716.5
      Conserved Domains (3) summary
      cd00872
      Location:44214
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:218579
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      cl14603
      Location:130
      C2; C2 domain
    2. NM_006219.3NP_006210.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1

      See identical proteins and their annotated locations for NP_006210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represent the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC020890, AC067728, AC117389, AI623206, BC114432
      Consensus CDS
      CCDS3104.1
      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
      Related
      ENSP00000501150.1, ENST00000674063.1
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      138652698..138834928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448312.1XP_047304268.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    2. XM_006713659.4XP_006713722.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      See identical proteins and their annotated locations for XP_006713722.1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
      Related
      ENSP00000418143.1, ENST00000477593.5
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_047448311.1XP_047304267.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    4. XM_047448314.1XP_047304270.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    5. XM_011512895.3XP_011511197.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      See identical proteins and their annotated locations for XP_011511197.1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    6. XM_047448307.1XP_047304263.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    7. XM_047448313.1XP_047304269.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    8. XM_047448308.1XP_047304264.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    9. XM_047448309.1XP_047304265.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    10. XM_047448310.1XP_047304266.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    11. XM_017006619.2XP_016862108.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
      Related
      ENSP00000289153.2, ENST00000289153.6
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    12. XM_047448315.1XP_047304271.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      141393413..141575643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346855.1XP_054202830.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    2. XM_054346850.1XP_054202825.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    3. XM_054346854.1XP_054202829.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    4. XM_054346856.1XP_054202831.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    5. XM_054346849.1XP_054202824.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    6. XM_054346857.1XP_054202832.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    7. XM_054346852.1XP_054202827.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    8. XM_054346851.1XP_054202826.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    9. XM_054346853.1XP_054202828.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      D3DNF0, P42338, Q24JU2
    10. XM_054346858.1XP_054202833.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3