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    Slc52a2 solute carrier protein 52, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 52710, updated on 14-May-2024

    Summary

    Official Symbol
    Slc52a2provided by MGI
    Official Full Name
    solute carrier protein 52, member 2provided by MGI
    Primary source
    MGI:MGI:1289288
    See related
    Ensembl:ENSMUSG00000022560 AllianceGenome:MGI:1289288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAR2; RFT1; Rfvt2; mRFT1; GPCR42; Gpr172b; D15Ertd747e; 2010003P03Rik
    Summary
    Predicted to enable 4-hydroxybutyrate receptor activity and riboflavin transmembrane transporter activity. Predicted to be involved in riboflavin transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 16.9), small intestine adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc52a2 in Genome Data Viewer
    Location:
    15 D3; 15 36.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76422994..76432078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76538814..76547878)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 249 Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene predicted gene, 35739 Neighboring gene STARR-positive B cell enhancer ABC_E9913 Neighboring gene aarF domain containing kinase 5 Neighboring gene cleavage and polyadenylation specific factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in flavin adenine dinucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in flavin adenine dinucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in riboflavin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in riboflavin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in riboflavin transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 52, riboflavin transporter, member 2
    Names
    G protein-coupled receptor 172B
    PERV-A receptor 2 homolog
    porcine endogenous retrovirus A receptor 2 homolog
    riboflavin transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029643.4NP_083919.1  solute carrier family 52, riboflavin transporter, member 2

      See identical proteins and their annotated locations for NP_083919.1

      Status: VALIDATED

      Source sequence(s)
      AC157566, AK029579, BY148057
      Consensus CDS
      CCDS27575.1
      UniProtKB/Swiss-Prot
      Q8CCV8, Q9D8F3
      Related
      ENSMUSP00000023220.9, ENSMUST00000023220.10
      Conserved Domains (1) summary
      pfam06237
      Location:282376
      DUF1011; Protein of unknown function (DUF1011)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76422994..76432078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521151.5XP_006521214.1  solute carrier family 52, riboflavin transporter, member 2 isoform X1

      See identical proteins and their annotated locations for XP_006521214.1

      UniProtKB/Swiss-Prot
      Q8CCV8, Q9D8F3
      Conserved Domains (1) summary
      pfam06237
      Location:282376
      DUF1011; Protein of unknown function (DUF1011)

    RNA

    1. XR_004938852.1 RNA Sequence