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    Txndc17 thioredoxin domain containing 17 [ Mus musculus (house mouse) ]

    Gene ID: 52700, updated on 18-Sep-2024

    Summary

    Official Symbol
    Txndc17provided by MGI
    Official Full Name
    thioredoxin domain containing 17provided by MGI
    Primary source
    MGI:MGI:1289248
    See related
    Ensembl:ENSMUSG00000020803 AllianceGenome:MGI:1289248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRP14; Txnl5; D11Ertd672e; 4831443O22Rik
    Summary
    Predicted to enable peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 53.8), large intestine adult (RPKM 37.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Txndc17 in Genome Data Viewer
    Location:
    11 B4; 11 43.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72098380..72101313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72207554..72210487)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene PITPNM family member 3 Neighboring gene predicted gene, 46286 Neighboring gene STARR-seq mESC enhancer starr_29899 Neighboring gene RIKEN cDNA 4933427D14 gene Neighboring gene RIKEN cDNA 4930563E22 gene Neighboring gene STARR-positive B cell enhancer ABC_E3970 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72029072-72029181 Neighboring gene predicted gene, 57849 Neighboring gene mediator complex subunit 31 Neighboring gene solute carrier family 13 (sodium-dependent citrate transporter), member 5 Neighboring gene predicted gene, 34252

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-disulfide reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase (NAD(P)H) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 17
    Names
    14 kDa thioredoxin-related protein
    protein 42-9-9
    putative 42-9-9 protein
    thioredoxin-like 5
    thioredoxin-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026559.3NP_080835.1  thioredoxin domain-containing protein 17

      See identical proteins and their annotated locations for NP_080835.1

      Status: VALIDATED

      Source sequence(s)
      AK076425
      Consensus CDS
      CCDS24980.1
      UniProtKB/Swiss-Prot
      Q3TE14, Q921A9, Q9CQM5, Q9D0Y4
      Related
      ENSMUSP00000021158.4, ENSMUST00000021158.4
      Conserved Domains (1) summary
      cd02952
      Location:4121
      TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72098380..72101313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)