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    Setd3 SET domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 52690, updated on 26-Jun-2021

    Summary

    Official Symbol
    Setd3provided by MGI
    Official Full Name
    SET domain containing 3provided by MGI
    Primary source
    MGI:MGI:1289184
    See related
    Ensembl:ENSMUSG00000056770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd771; D12Ertd771e; 2610102I01Rik; 2610305M23Rik; 6030490B17Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.5), bladder adult (RPKM 14.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Setd3 in Genome Data Viewer
    Location:
    12 F1; 12 59.23 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108072690..108145616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108106431..108179345, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109344641..109417494, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33341 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C Neighboring gene hedgehog interacting protein-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    actin-histidine N-methyltransferase
    Names
    SET domain-containing protein 3
    endothelial differentiation inhibitory protein D10
    histone-lysine N-methyltransferase setd3
    protein-L-histidine N-tele-methyltransferase
    NP_001351195.1
    NP_001351196.1
    NP_001351197.1
    NP_001351198.1
    NP_001351199.1
    NP_082538.2
    XP_006516141.4
    XP_006516144.4
    XP_017170622.1
    XP_030102671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364266.1NP_001351195.1  actin-histidine N-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:112146
      SET; SET domain
      pfam09273
      Location:357482
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    2. NM_001364267.1NP_001351196.1  actin-histidine N-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:72106
      SET; SET domain
      pfam09273
      Location:317442
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    3. NM_001364268.1NP_001351197.1  actin-histidine N-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:105256
      SET; SET domain
      pfam09273
      Location:292417
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    4. NM_001364269.1NP_001351198.1  actin-histidine N-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam09273
      Location:222347
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:1201
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    5. NM_001364270.1NP_001351199.1  actin-histidine N-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam09273
      Location:164289
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:1143
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    6. NM_028262.3NP_082538.2  actin-histidine N-methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_082538.2

      Status: VALIDATED

      Source sequence(s)
      AK031371, BC016123, BY087049
      Consensus CDS
      CCDS26159.1
      UniProtKB/Swiss-Prot
      Q91WC0
      Related
      ENSMUSP00000066413.8, ENSMUST00000071095.14
      Conserved Domains (2) summary
      pfam00856
      Location:105180
      SET; SET domain
      pfam09273
      Location:353475
      Rubis-subs-bind; Rubisco LSMT substrate-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108072690..108145616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315133.1XP_017170622.1  actin-histidine N-methyltransferase isoform X2

      Conserved Domains (2) summary
      pfam09273
      Location:299424
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:87278
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    2. XM_006516081.4XP_006516144.4  actin-histidine N-methyltransferase isoform X3

      Conserved Domains (2) summary
      pfam09273
      Location:164289
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:1143
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    3. XM_030246811.2XP_030102671.1  actin-histidine N-methyltransferase isoform X1

      Conserved Domains (2) summary
      pfam09273
      Location:222347
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:1201
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    4. XM_006516078.5XP_006516141.4  actin-histidine N-methyltransferase isoform X1

      Conserved Domains (2) summary
      pfam09273
      Location:222347
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:1201
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins

    RNA

    1. XR_003950066.2 RNA Sequence

    2. XR_003950065.1 RNA Sequence

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