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    Setd3 SET domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 52690, updated on 2-Oct-2018

    Summary

    Official Symbol
    Setd3provided by MGI
    Official Full Name
    SET domain containing 3provided by MGI
    Primary source
    MGI:MGI:1289184
    See related
    Ensembl:ENSMUSG00000056770 Vega:OTTMUSG00000019487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd771e; 2610102I01Rik; 2610305M23Rik; 6030490B17Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.5), bladder adult (RPKM 14.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Setd3 in Genome Data Viewer
    Location:
    12 F1; 12 59.23 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (108106431..108179462, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109344641..109417494, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33341 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone methyltransferase activity (H3-K36 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone methyltransferase activity (H3-K36 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity (H3-K4 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone methyltransferase activity (H3-K4 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K36 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine monomethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-lysine trimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase setd3
    Names
    SET domain-containing protein 3
    endothelial differentiation inhibitory protein D10
    NP_082538.2
    XP_006516141.3
    XP_006516142.1
    XP_006516143.1
    XP_006516144.3
    XP_006516145.1
    XP_006516146.1
    XP_006516147.3
    XP_017170622.1
    XP_017170623.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364266.1NP_001351195.1  histone-lysine N-methyltransferase setd3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:112146
      SET; SET domain
      pfam09273
      Location:357482
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    2. NM_001364267.1NP_001351196.1  histone-lysine N-methyltransferase setd3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:72106
      SET; SET domain
      pfam09273
      Location:317442
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    3. NM_001364268.1NP_001351197.1  histone-lysine N-methyltransferase setd3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (2) summary
      pfam00856
      Location:105256
      SET; SET domain
      pfam09273
      Location:292417
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    4. NM_001364269.1NP_001351198.1  histone-lysine N-methyltransferase setd3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (1) summary
      pfam09273
      Location:222347
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    5. NM_001364270.1NP_001351199.1  histone-lysine N-methyltransferase setd3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC152059, AL583892
      Conserved Domains (1) summary
      pfam09273
      Location:164289
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    6. NM_028262.3NP_082538.2  histone-lysine N-methyltransferase setd3 isoform 2

      See identical proteins and their annotated locations for NP_082538.2

      Status: VALIDATED

      Source sequence(s)
      AK031371, BC016123, BY087049
      Consensus CDS
      CCDS26159.1
      UniProtKB/Swiss-Prot
      Q91WC0
      Related
      ENSMUSP00000066413.7, OTTMUSP00000021007, ENSMUST00000071095.13, OTTMUST00000046524
      Conserved Domains (2) summary
      pfam00856
      Location:105180
      SET; SET domain
      pfam09273
      Location:353475
      Rubis-subs-bind; Rubisco LSMT substrate-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      108106431..108179462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516081.3XP_006516144.3  histone-lysine N-methyltransferase setd3 isoform X4

    2. XM_006516078.3XP_006516141.3  histone-lysine N-methyltransferase setd3 isoform X1

    3. XM_017315134.1XP_017170623.1  histone-lysine N-methyltransferase setd3 isoform X6

      Conserved Domains (2) summary
      pfam00856
      Location:105256
      SET; SET domain
      pfam09273
      Location:292417
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    4. XM_006516083.3XP_006516146.1  histone-lysine N-methyltransferase setd3 isoform X8

      UniProtKB/Swiss-Prot
      Q91WC0
      Conserved Domains (1) summary
      pfam09273
      Location:164289
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    5. XM_017315133.1XP_017170622.1  histone-lysine N-methyltransferase setd3 isoform X5

    6. XM_006516082.3XP_006516145.1  histone-lysine N-methyltransferase setd3 isoform X7

      Conserved Domains (1) summary
      pfam09273
      Location:222347
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    7. XM_006516079.3XP_006516142.1  histone-lysine N-methyltransferase setd3 isoform X2

      Conserved Domains (2) summary
      pfam00856
      Location:112146
      SET; SET domain
      pfam09273
      Location:357482
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    8. XM_006516080.3XP_006516143.1  histone-lysine N-methyltransferase setd3 isoform X3

      Conserved Domains (2) summary
      pfam00856
      Location:72106
      SET; SET domain
      pfam09273
      Location:317442
      Rubis-subs-bind; Rubisco LSMT substrate-binding
    9. XM_006516084.3XP_006516147.3  histone-lysine N-methyltransferase setd3 isoform X9

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