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    Esyt2 extended synaptotagmin-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 52635, updated on 23-Jun-2021

    Summary

    Official Symbol
    Esyt2provided by MGI
    Official Full Name
    extended synaptotagmin-like protein 2provided by MGI
    Primary source
    MGI:MGI:1261845
    See related
    Ensembl:ENSMUSG00000021171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam62; Fam62b; CHR2SYT; D12Ertd551; D12Ertd551e; 2410017M09Rik; 4921504I16Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Esyt2 in Genome Data Viewer
    Location:
    12 F2; 12 62.65 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116242903..116354555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116279283..116390935)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (117519695..117611571)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46330 Neighboring gene dynein 2 intermediate chain 1 Neighboring gene RIKEN cDNA D430020J02 gene Neighboring gene non-SMC condensin II complex, subunit G2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1228

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intrinsic component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intrinsic component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    extended synaptotagmin-2
    Names
    E-Syt2
    chr2 synaptotagmin
    family with sequence similarity 62 (C2 domain containing), member B
    family with sequence similarity 62, member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028731.5NP_083007.2  extended synaptotagmin-2

      See identical proteins and their annotated locations for NP_083007.2

      Status: VALIDATED

      Source sequence(s)
      AI838753, AK014813, AK044360, BC059230
      Consensus CDS
      CCDS26211.1
      UniProtKB/Swiss-Prot
      Q3TZZ7
      Related
      ENSMUSP00000098548.3, ENSMUST00000100986.4
      Conserved Domains (4) summary
      cd04030
      Location:710835
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461566
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      116242903..116354555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246808.1XP_030102668.1  extended synaptotagmin-2 isoform X2

      Conserved Domains (4) summary
      cd04030
      Location:744869
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    2. XM_017315129.2XP_017170618.1  extended synaptotagmin-2 isoform X1

      Conserved Domains (4) summary
      cd04030
      Location:744864
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    3. XM_011244139.3XP_011242441.1  extended synaptotagmin-2 isoform X3

      Conserved Domains (4) summary
      cd04030
      Location:731851
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461587
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    4. XM_030246810.1XP_030102670.1  extended synaptotagmin-2 isoform X5

      Conserved Domains (4) summary
      cd04030
      Location:710830
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461566
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    5. XM_017315130.2XP_017170619.1  extended synaptotagmin-2 isoform X2

      Conserved Domains (4) summary
      cd04030
      Location:744869
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    6. XM_036157525.1XP_036013418.1  extended synaptotagmin-2 isoform X2

      Conserved Domains (4) summary
      cd04030
      Location:744869
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    7. XM_006516072.4XP_006516135.1  extended synaptotagmin-2 isoform X4

    8. XM_006516075.4XP_006516138.1  extended synaptotagmin-2 isoform X7

      Conserved Domains (2) summary
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    9. XM_036157526.1XP_036013419.1  extended synaptotagmin-2 isoform X8

      Conserved Domains (2) summary
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    10. XM_017315131.1XP_017170620.1  extended synaptotagmin-2 isoform X6

      Conserved Domains (4) summary
      cd04030
      Location:578698
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:295434
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:143263
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:4128
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RNA

    1. XR_003950062.1 RNA Sequence

    2. XR_003950063.1 RNA Sequence

    3. XR_004937526.1 RNA Sequence

    4. XR_004937527.1 RNA Sequence

    5. XR_001780466.2 RNA Sequence

    6. XR_003950064.1 RNA Sequence

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