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    Suz12 SUZ12 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 52615, updated on 2-Oct-2018

    Summary

    Official Symbol
    Suz12provided by MGI
    Official Full Name
    SUZ12 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1261758
    See related
    Ensembl:ENSMUSG00000017548 Vega:OTTMUSG00000000192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI195385; AU016842; AW536442; mKIAA0160; D11Ertd530e; 2610028O16Rik
    Summary
    This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Broad expression in liver E14 (RPKM 18.5), CNS E11.5 (RPKM 16.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See Suz12 in Genome Data Viewer
    Location:
    11 B5; 11 47.36 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (79993106..80034123)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (79806608..79847625)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene UTP6 small subunit processome component Neighboring gene predicted gene, 30875 Neighboring gene cytokine receptor-like factor 3 Neighboring gene ATPase family, AAA domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone methyltransferase activity (H3-K27 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K27 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb protein Suz12
    Names
    suppressor of zeste 12 homolog
    suppressor of zeste 12 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163018.1NP_001156490.1  polycomb protein Suz12 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK076010, BC064461
      Consensus CDS
      CCDS48860.1
      UniProtKB/Swiss-Prot
      Q80U70
      UniProtKB/TrEMBL
      E9PW15
      Related
      ENSMUSP00000126932.1, ENSMUST00000163272.1
      Conserved Domains (1) summary
      pfam09733
      Location:525659
      VEFS-Box; VEFS-Box of polycomb protein
    2. NM_199196.2NP_954666.1  polycomb protein Suz12 isoform 1

      See identical proteins and their annotated locations for NP_954666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK076010, BC064461
      Consensus CDS
      CCDS25125.1
      UniProtKB/Swiss-Prot
      Q80U70
      Related
      ENSMUSP00000017692.8, OTTMUSP00000000248, ENSMUST00000017692.14, OTTMUST00000000571
      Conserved Domains (1) summary
      pfam09733
      Location:548682
      VEFS-Box; VEFS-Box of polycomb protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      79993106..80034123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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