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    Tspan14 tetraspanin 14 [ Mus musculus (house mouse) ]

    Gene ID: 52588, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tspan14provided by MGI
    Official Full Name
    tetraspanin 14provided by MGI
    Primary source
    MGI:MGI:1196325
    See related
    Ensembl:ENSMUSG00000037824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tm4sf1; Tm4sf14; AA958793; tspan-14; D14Ertd226; D14Ertd226e
    Expression
    Ubiquitous expression in placenta adult (RPKM 50.8), kidney adult (RPKM 41.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tspan14 in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40628384..40689030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (40906427..40967073, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (41719733..41780096, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene SH2 domain containing 4B Neighboring gene VISTA enhancer mm1503 Neighboring gene predicted gene, 31839 Neighboring gene peroxiredoxin like 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36554

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tetraspanin-14
    Names
    transmembrane 4 superfamily member 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316748.1NP_001303677.1  tetraspanin-14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC108430, AK030593, BG807867
      Consensus CDS
      CCDS26956.1
      UniProtKB/Swiss-Prot
      Q8QZY6
      Related
      ENSMUSP00000153208.2, ENSMUST00000224209.2
      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    2. NM_145928.2NP_666040.1  tetraspanin-14

      See identical proteins and their annotated locations for NP_666040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154597, AK030593, BG807867, BY209307
      Consensus CDS
      CCDS26956.1
      UniProtKB/Swiss-Prot
      Q8QZY6
      Related
      ENSMUSP00000035263.6, ENSMUST00000047652.6
      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40628384..40689030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316081.2XP_017171570.1  tetraspanin-14 isoform X2

      Conserved Domains (1) summary
      cd03159
      Location:47167
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    2. XM_036158754.1XP_036014647.1  tetraspanin-14 isoform X1

      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    3. XM_036158755.1XP_036014648.1  tetraspanin-14 isoform X1

      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    4. XM_006519261.2XP_006519324.1  tetraspanin-14 isoform X1

      See identical proteins and their annotated locations for XP_006519324.1

      UniProtKB/Swiss-Prot
      Q8QZY6
      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    5. XM_036158753.1XP_036014646.1  tetraspanin-14 isoform X1

      Conserved Domains (1) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
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