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    Parp8 poly (ADP-ribose) polymerase family, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 52552, updated on 9-Sep-2018

    Summary

    Official Symbol
    Parp8provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 8provided by MGI
    Primary source
    MGI:MGI:1098713
    See related
    Ensembl:ENSMUSG00000021725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD16; D13Ertd275e; 2810430O08Rik
    Expression
    Broad expression in CNS E18 (RPKM 8.9), CNS E14 (RPKM 6.0) and 22 other tissues See more
    Orthologs

    Genomic context

    See Parp8 in Genome Data Viewer
    Location:
    13 D2.3; 13 65.32 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (116850842..117025925, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (117643631..117814323, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29764 Neighboring gene RIKEN cDNA 4930435F18 gene Neighboring gene predicted gene, 29767 Neighboring gene predicted gene 6416

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 8
    Names
    ADP-ribosyltransferase diphtheria toxin-like 16
    PARP-8
    NP_001074478.1
    XP_006517781.1
    XP_006517782.1
    XP_006517783.1
    XP_011242981.1
    XP_011242982.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081009.1NP_001074478.1  poly [ADP-ribose] polymerase 8

      See identical proteins and their annotated locations for NP_001074478.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154224, CT025610
      Consensus CDS
      CCDS36790.1
      UniProtKB/TrEMBL
      F8WIK2
      Related
      ENSMUSP00000022239.6, ENSMUST00000022239.7
      Conserved Domains (1) summary
      cd01341
      Location:731855
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      116850842..117025925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517719.3XP_006517782.1  poly [ADP-ribose] polymerase 8 isoform X3

      See identical proteins and their annotated locations for XP_006517782.1

      UniProtKB/TrEMBL
      F8WIK2
      Conserved Domains (1) summary
      cd01341
      Location:731855
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    2. XM_006517720.1XP_006517783.1  poly [ADP-ribose] polymerase 8 isoform X5

      Conserved Domains (1) summary
      cd01341
      Location:445569
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    3. XM_011244679.2XP_011242981.1  poly [ADP-ribose] polymerase 8 isoform X2

      Conserved Domains (1) summary
      cd01341
      Location:771895
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    4. XM_006517718.3XP_006517781.1  poly [ADP-ribose] polymerase 8 isoform X1

      Conserved Domains (1) summary
      cd01341
      Location:771895
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    5. XM_011244680.2XP_011242982.1  poly [ADP-ribose] polymerase 8 isoform X4

      Conserved Domains (2) summary
      pfam15730
      Location:33109
      DUF4680; Domain of unknown function (DUF4680)
      cl00283
      Location:559608
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027272.3: Suppressed sequence

      Description
      NM_027272.3: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PARP8 (GeneID:79668).
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