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    Nhp2 NHP2 ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 52530, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nhp2provided by MGI
    Official Full Name
    NHP2 ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1098547
    See related
    Ensembl:ENSMUSG00000001056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; NH; Nola2; D11Ertd175; D11Ertd175e; 2410130M07Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 67.7), liver E14 (RPKM 49.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nhp2 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51510600..51514545)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51619773..51623718)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51433275..51437216)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene predicted gene, 30058 Neighboring gene NEDD4 binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U3 snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables box H/ACA snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cleavage involved in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in snoRNA guided rRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of box H/ACA snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of box H/ACA telomerase RNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    H/ACA ribonucleoprotein complex subunit 2
    Names
    H/ACA small nucleolar RNPs
    NHP2 ribonucleoprotein homolog
    nucleolar protein family A, member 2
    snoRNP protein NHP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364736.1NP_001351665.1  H/ACA ribonucleoprotein complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK019134, AV472909, CR518445
      Conserved Domains (1) summary
      cl00600
      Location:4677
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    2. NM_026631.4NP_080907.1  H/ACA ribonucleoprotein complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_080907.1

      Status: VALIDATED

      Source sequence(s)
      AL645602
      Consensus CDS
      CCDS24655.1
      UniProtKB/Swiss-Prot
      Q9CRB2
      Related
      ENSMUSP00000120014.2, ENSMUST00000127405.2
      Conserved Domains (1) summary
      pfam01248
      Location:46137
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RNA

    1. NR_157294.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK019134, BF467095, CR518445

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51510600..51514545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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