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    Angel2 angel homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 52477, updated on 23-Jun-2021

    Summary

    Official Symbol
    Angel2provided by MGI
    Official Full Name
    angel homolog 2provided by MGI
    Primary source
    MGI:MGI:1196310
    See related
    Ensembl:ENSMUSG00000026634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI845692; D1Ertd396; D1Ertd654; D1Ertd396e; D1Ertd654e; 2610307I21Rik; 5730410O10Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 13.5), CNS E18 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Angel2 in Genome Data Viewer
    Location:
    1 H6; 1 96.28 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190657305..190679160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190925108..190946963)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (192752424..192769617)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39738 Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene predicted gene, 51740 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2 Neighboring gene predicted gene, 31373

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199020.1NP_001185949.1  protein angel homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001185949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of an in-frame downstream translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC112675, AK135709, CJ081516
      Consensus CDS
      CCDS56667.1
      UniProtKB/Swiss-Prot
      Q8K1C0
      Related
      ENSMUSP00000027947.7, ENSMUST00000027947.13
      Conserved Domains (1) summary
      cl00490
      Location:147520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    2. NM_001357131.1NP_001344060.1  protein angel homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Consensus CDS
      CCDS56667.1
      Related
      ENSMUSP00000106524.2, ENSMUST00000110899.7
      Conserved Domains (1) summary
      cl00490
      Location:147520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. NM_001357132.1NP_001344061.1  protein angel homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Conserved Domains (1) summary
      cl00490
      Location:1373
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. NM_001357133.1NP_001344062.1  protein angel homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Consensus CDS
      CCDS56667.1
      Related
      ENSMUST00000144693.2
      Conserved Domains (1) summary
      cl00490
      Location:147520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    5. NM_001357134.1NP_001344063.1  protein angel homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Conserved Domains (1) summary
      cl00490
      Location:1373
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    6. NM_021421.4NP_067396.3  protein angel homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_067396.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC112675, AK158731
      Consensus CDS
      CCDS15612.1
      UniProtKB/Swiss-Prot
      Q8K1C0
      Related
      ENSMUSP00000064556.8, ENSMUST00000066632.14
      Conserved Domains (1) summary
      cl00490
      Location:169542
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RNA

    1. NR_151630.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Related
      ENSMUST00000123384.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      190657305..190679160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255505.2XP_030111365.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    2. XM_030255501.2XP_030111361.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. XM_017321690.3XP_017177179.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. XM_036152389.1XP_036008282.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    5. XM_006497186.3XP_006497249.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    6. XM_006497184.5XP_006497247.1  protein angel homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006497247.1

      UniProtKB/Swiss-Prot
      Q8K1C0
      Conserved Domains (1) summary
      cl00490
      Location:147520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    7. XM_030255504.2XP_030111364.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    8. XM_006497183.5XP_006497246.1  protein angel homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006497246.1

      UniProtKB/Swiss-Prot
      Q8K1C0
      Conserved Domains (1) summary
      cl00490
      Location:147520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    9. XM_030255506.2XP_030111366.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RNA

    1. XR_373773.1 RNA Sequence

    2. XR_003956236.2 RNA Sequence

    3. XR_003956234.1 RNA Sequence

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