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    Rhpn2 rhophilin, Rho GTPase binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 52428, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rhpn2provided by MGI
    Official Full Name
    rhophilin, Rho GTPase binding protein 2provided by MGI
    Primary source
    MGI:MGI:1289234
    See related
    Ensembl:ENSMUSG00000030494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C85860; AA536890; D7Ertd784; D7Ertd784e; 1300002E07Rik
    Expression
    Broad expression in colon adult (RPKM 23.4), large intestine adult (RPKM 13.8) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Rhpn2 in Genome Data Viewer
    Location:
    7 B2; 7 21.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35033605..35091712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35334180..35392287)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (36119256..36177306)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 88 Neighboring gene G patch domain containing 1 Neighboring gene predicted gene, 51476 Neighboring gene Fanconi anemia core complex associated protein 24 Neighboring gene centrosomal protein 89 Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rhophilin-2
    Names
    GTP-Rho-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027897.4NP_082173.3  rhophilin-2

      See identical proteins and their annotated locations for NP_082173.3

      Status: VALIDATED

      Source sequence(s)
      AC154126, AK004849, CJ080543
      Consensus CDS
      CCDS21148.1
      UniProtKB/Swiss-Prot
      Q8BWR8
      Related
      ENSMUSP00000032705.7, ENSMUST00000032705.13
      Conserved Domains (3) summary
      cd09249
      Location:112496
      BRO1_Rhophilin_2; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-2
      cd11634
      Location:27108
      HR1_Rhophilin-2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2
      cd00992
      Location:522591
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      35033605..35091712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_391076.1 RNA Sequence

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