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    Sept11 septin 11 [ Mus musculus (house mouse) ]

    Gene ID: 52398, updated on 18-Nov-2018

    Summary

    Official Symbol
    Sept11provided by MGI
    Official Full Name
    septin 11provided by MGI
    Primary source
    MGI:MGI:1277214
    See related
    Ensembl:ENSMUSG00000058013 Vega:OTTMUSG00000055620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW548875; D5Ertd606e; 6230410I01Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 19.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Sept11 in Genome Data Viewer
    Location:
    5 E2; 5 47.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (93092423..93181736)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (93522483..93603984)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36764 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene sosondowah ankyrin repeat domain family member B Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene cyclin I Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic specialization of symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009818.2NP_001009818.1  septin-11 isoform 3

      See identical proteins and their annotated locations for NP_001009818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC134827, BC064466, CO042161
      Consensus CDS
      CCDS51549.1
      UniProtKB/Swiss-Prot
      Q8C1B7
      Related
      ENSMUSP00000074293.7, OTTMUSP00000072468, ENSMUST00000074733.10, OTTMUST00000137651
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    2. NM_001310669.1NP_001297598.1  septin-11 isoform 1

      See identical proteins and their annotated locations for NP_001297598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is 1 aa shorter compared to isoform 4.
      Source sequence(s)
      AC134827, AK028475
      Consensus CDS
      CCDS80331.1
      UniProtKB/Swiss-Prot
      Q8C1B7
      Related
      ENSMUSP00000143928.1, OTTMUSP00000072472, ENSMUST00000201421.3, OTTMUST00000137656
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    3. NM_001310671.1NP_001297600.1  septin-11 isoform 2

      See identical proteins and their annotated locations for NP_001297600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (2) is shorter at the C-terminus compared to isoform 4.
      Source sequence(s)
      AC134827
      Consensus CDS
      CCDS80332.1
      UniProtKB/Swiss-Prot
      Q8C1B7
      Related
      ENSMUSP00000144136.1, OTTMUSP00000072471, ENSMUST00000202308.3, OTTMUST00000137655
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    4. NM_001347377.1NP_001334306.1  septin-11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC134827
      Consensus CDS
      CCDS84906.1
      UniProtKB/TrEMBL
      A0A0J9YUL3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      93092423..93181736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320978.1XP_017176467.1  septin-11 isoform X4

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    2. XM_006535098.3XP_006535161.1  septin-11 isoform X1

      See identical proteins and their annotated locations for XP_006535161.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    3. XM_006535100.3XP_006535163.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_006535163.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    4. XM_006535101.3XP_006535164.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_006535164.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    5. XM_006535102.3XP_006535165.1  septin-11 isoform X4

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    6. XM_006535103.3XP_006535166.1  septin-11 isoform X5

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    7. XM_006535099.3XP_006535162.1  septin-11 isoform X1

      See identical proteins and their annotated locations for XP_006535162.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    8. XM_011249530.2XP_011247832.1  septin-11 isoform X1

      See identical proteins and their annotated locations for XP_011247832.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    9. XM_011249531.2XP_011247833.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_011247833.1

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    10. XM_011249532.2XP_011247834.1  septin-11 isoform X3

      Conserved Domains (1) summary
      cd01850
      Location:47315
      CDC_Septin; CDC/Septin GTPase family
    11. XM_017320982.1XP_017176471.1  septin-11 isoform X9

      Conserved Domains (1) summary
      cd01850
      Location:1249
      CDC_Septin; CDC/Septin GTPase family
    12. XM_017320979.1XP_017176468.1  septin-11 isoform X6

      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    13. XM_017320981.1XP_017176470.1  septin-11 isoform X8

      Related
      ENSMUSP00000143901.1, OTTMUSP00000072469, ENSMUST00000201700.3, OTTMUST00000137653
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    14. XM_017320980.1XP_017176469.1  septin-11 isoform X6

      UniProtKB/TrEMBL
      A0A0J9YUL3
      Related
      ENSMUSP00000144235.1, OTTMUSP00000072474, ENSMUST00000202217.2, OTTMUST00000137658
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    15. XM_006535104.3XP_006535167.1  septin-11 isoform X6

      See identical proteins and their annotated locations for XP_006535167.1

      UniProtKB/TrEMBL
      A0A0J9YUL3
      Conserved Domains (1) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
    16. XM_006535108.3XP_006535171.1  septin-11 isoform X9

      Conserved Domains (1) summary
      cd01850
      Location:1249
      CDC_Septin; CDC/Septin GTPase family
    17. XM_006535106.3XP_006535169.1  septin-11 isoform X7

      Conserved Domains (1) summary
      cd01850
      Location:36304
      CDC_Septin; CDC/Septin GTPase family

    RNA

    1. XR_001784719.1 RNA Sequence

    2. XR_389284.3 RNA Sequence

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