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    Cdca8 cell division cycle associated 8 [ Mus musculus (house mouse) ]

    Gene ID: 52276, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdca8provided by MGI
    Official Full Name
    cell division cycle associated 8provided by MGI
    Primary source
    MGI:MGI:1196274
    See related
    Ensembl:ENSMUSG00000028873 AllianceGenome:MGI:1196274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BOR; DasraB; MESRGP; Borealin; D4Ertd421e; 4831429J16Rik
    Summary
    Predicted to be involved in mitotic metaphase chromosome alignment. Located in chromocenter. Is expressed in several structures, including central nervous system; early embryo; gonad; metanephros; and retina. Orthologous to human CDCA8 (cell division cycle associated 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 40.8), liver E14.5 (RPKM 38.3) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdca8 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124812258..124830710, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124918465..124936917, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene yrdC domain containing (E.coli) Neighboring gene mannosidase, endo-alpha-like Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene predicted gene 12930 Neighboring gene predicted gene, 32371

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromosome passenger complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    borealin
    Names
    MESrg
    cell division cycle-associated protein 8
    embryonic stem cell-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026560.4NP_080836.3  borealin

      See identical proteins and their annotated locations for NP_080836.3

      Status: VALIDATED

      Source sequence(s)
      AK077717, BY137168
      Consensus CDS
      CCDS18631.1
      UniProtKB/Swiss-Prot
      B1ARX0, B1ARX1, Q6NVD3, Q8BHB1, Q8BHQ5, Q8BHQ9, Q8BHX3, Q9CRN4, Q9CS02, Q9CTF4
      Related
      ENSMUSP00000081319.4, ENSMUST00000084296.10
      Conserved Domains (2) summary
      pfam10444
      Location:2276
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:170284
      Borealin; Cell division cycle-associated protein 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124812258..124830710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)