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    Anapc4 anaphase promoting complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 52206, updated on 31-Jan-2019

    Summary

    Official Symbol
    Anapc4provided by MGI
    Official Full Name
    anaphase promoting complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1098673
    See related
    Ensembl:ENSMUSG00000029176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC4; D5Ertd249e; 2610306D21Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 38.1), CNS E14 (RPKM 29.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See Anapc4 in Genome Data Viewer
    Location:
    5 C1; 5 28.81 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (52834135..52866734)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (53225374..53257973)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4 Neighboring gene predicted gene, 30241 Neighboring gene RIKEN cDNA 5033403H07 gene Neighboring gene predicted gene, 30301

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 4
    Names
    cyclosome subunit 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024213.2NP_077175.1  anaphase-promoting complex subunit 4

      See identical proteins and their annotated locations for NP_077175.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102766
      Consensus CDS
      CCDS19290.1
      UniProtKB/Swiss-Prot
      Q91W96
      UniProtKB/TrEMBL
      Q3TM92
      Related
      ENSMUSP00000031072.7, ENSMUST00000031072.13
      Conserved Domains (4) summary
      pfam12894
      Location:1057
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:232431
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
      sd00039
      Location:2459
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:26115
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      52834135..52866734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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