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    Anapc4 anaphase promoting complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 52206, updated on 23-Jun-2021

    Summary

    Official Symbol
    Anapc4provided by MGI
    Official Full Name
    anaphase promoting complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1098673
    See related
    Ensembl:ENSMUSG00000029176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP; APC4; D5Ertd249; D5Ertd249e; 2610306D21Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 38.1), CNS E14 (RPKM 29.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Anapc4 in Genome Data Viewer
    Location:
    5 C1; 5 28.81 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52991477..53024076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52834135..52866734)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (53225374..53257973)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4 Neighboring gene predicted gene, 30241 Neighboring gene predicted gene 43664

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 4
    Names
    cyclosome subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024213.2NP_077175.1  anaphase-promoting complex subunit 4

      See identical proteins and their annotated locations for NP_077175.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102766
      Consensus CDS
      CCDS19290.1
      UniProtKB/Swiss-Prot
      Q91W96
      UniProtKB/TrEMBL
      Q3TM92
      Related
      ENSMUSP00000031072.8, ENSMUST00000031072.14
      Conserved Domains (4) summary
      pfam12894
      Location:1057
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:232431
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
      sd00039
      Location:2459
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:26115
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      52991477..53024076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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