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    ATP5PF ATP synthase peripheral stalk subunit F6 [ Homo sapiens (human) ]

    Gene ID: 522, updated on 17-Jun-2024

    Summary

    Official Symbol
    ATP5PFprovided by HGNC
    Official Full Name
    ATP synthase peripheral stalk subunit F6provided by HGNC
    Primary source
    HGNC:HGNC:847
    See related
    Ensembl:ENSG00000154723 MIM:603152; AllianceGenome:HGNC:847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F6; CF6; ATP5; ATPM; ATP5A; ATP5J
    Summary
    Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in heart (RPKM 71.0), kidney (RPKM 49.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ATP5PF in Genome Data Viewer
    Location:
    21q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25724500..25735653, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (24082042..24093216, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27096811..27107964, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene junctional adhesion molecule 2 Neighboring gene uncharacterized LOC124905002 Neighboring gene ferredoxin 1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27104507-27105344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13232 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27107035-27107690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13234 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene LLPH pseudogene 2 Neighboring gene uncharacterized LOC105372757

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (ATP5J) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    ATP synthase-coupling factor 6, mitochondrial
    Names
    ATP synthase subunit h
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
    ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6
    ATPase subunit F6
    coupling factor 6
    mitochondrial ATP synthase, coupling factor 6
    mitochondrial ATP synthase, subunit F6
    mitochondrial ATPase coupling factor 6
    proliferation-inducing protein 36
    NP_001003696.1
    NP_001003697.1
    NP_001003701.1
    NP_001003703.1
    NP_001307195.1
    NP_001307196.1
    NP_001676.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003696.2NP_001003696.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001003696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AI085837, BC001178, BC066310, BU174560
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Related
      ENSP00000382959.3, ENST00000400087.7
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    2. NM_001003697.2NP_001003697.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001003697.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AI085837, BC001178, BC066310, BG938438
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Related
      ENSP00000382962.3, ENST00000400090.7
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    3. NM_001003701.2NP_001003701.1  ATP synthase-coupling factor 6, mitochondrial isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, compared to variant 1. The predicted isoform (b) is longer, and it contains a distinct N-terminus, compared to isoform a. The translation initiation site for this transcript is inferred.
      Source sequence(s)
      AI085837, BC001178, BC066310, BI093033
      Consensus CDS
      CCDS46637.1
      UniProtKB/TrEMBL
      Q6NZ59
      Related
      ENSP00000389649.2, ENST00000457143.6
      Conserved Domains (1) summary
      pfam05511
      Location:9104
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    4. NM_001003703.2NP_001003703.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001003703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AI085837, BC001178, BC066310, BQ268216
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Related
      ENSP00000284971.3, ENST00000284971.8
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    5. NM_001320266.2NP_001307195.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AA364611, AI085837, BQ268216, HY146471
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Related
      ENSP00000382966.1, ENST00000400094.5
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    6. NM_001320267.2NP_001307196.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AI085837, BQ268216, CN260182, HY146471
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    7. NM_001685.5NP_001676.2  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001676.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
      Source sequence(s)
      AI085837, BC001178, BC066310
      Consensus CDS
      CCDS13574.1
      UniProtKB/Swiss-Prot
      J3KQ83, P18859
      UniProtKB/TrEMBL
      Q6IB54, Q6NZ59
      Related
      ENSP00000382965.3, ENST00000400093.3
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      25724500..25735653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      24082042..24093216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)