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    Pbk PDZ binding kinase [ Mus musculus (house mouse) ]

    Gene ID: 52033, updated on 5-Aug-2018

    Summary

    Official Symbol
    Pbkprovided by MGI
    Official Full Name
    PDZ binding kinaseprovided by MGI
    Primary source
    MGI:MGI:1289156
    See related
    Ensembl:ENSMUSG00000022033 Vega:OTTMUSG00000027681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TOPK; AW538537; D14Ertd732e; 2810434B10Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 15.6) and 10 other tissues See more
    Orthologs

    Genomic context

    See Pbk in Genome Data Viewer
    Location:
    14 D1; 14 34.36 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (65805911..65817822)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66424748..66436659)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene nuclear GTPase, germinal center associated Neighboring gene predicted gene, 30245 Neighboring gene scavenger receptor class A, member 5 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene coiled-coil domain containing 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lymphokine-activated killer T-cell-originated protein kinase
    Names
    MAPKK-like protein kinase
    T-LAK cell-originated protein kinase
    NP_075698.1
    XP_006519320.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023209.2NP_075698.1  lymphokine-activated killer T-cell-originated protein kinase

      See identical proteins and their annotated locations for NP_075698.1

      Status: PROVISIONAL

      Source sequence(s)
      AB041882
      Consensus CDS
      CCDS27215.1
      UniProtKB/Swiss-Prot
      Q9JJ78
      Related
      ENSMUSP00000022612.3, OTTMUSP00000034645, ENSMUST00000022612.9, OTTMUST00000068488
      Conserved Domains (2) summary
      cd14001
      Location:31318
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
      pfam00069
      Location:33315
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      65805911..65817822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519257.3XP_006519320.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006519320.1

      UniProtKB/Swiss-Prot
      Q9JJ78
      Conserved Domains (2) summary
      cd14001
      Location:31318
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
      pfam00069
      Location:33315
      Pkinase; Protein kinase domain
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