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    Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit [ Mus musculus (house mouse) ]

    Gene ID: 52014, updated on 24-Apr-2022

    Summary

    Official Symbol
    Nus1provided by MGI
    Official Full Name
    NUS1 dehydrodolichyl diphosphate synthase subunitprovided by MGI
    Primary source
    MGI:MGI:1196365
    See related
    Ensembl:ENSMUSG00000023068 AllianceGenome:MGI:1196365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU019165; AW538011; BC003223; D10Ertd438e; 1600027K07Rik
    Summary
    Enables prenyltransferase activity. Acts upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 26.3), adrenal adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nus1 in Genome Data Viewer
    Location:
    10 B3; 10 26.64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (52293643..52316288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (52417547..52440192)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (52137353..52159998)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 10 Neighboring gene nephrocan Neighboring gene predicted gene, 47612 Neighboring gene zinc finger protein, autosomal, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7199

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to dehydrodolichyl diphosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dehydrodolichyl diphosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prenyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to prenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dolichol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within dolichol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dolichyl diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein mannosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intracellular cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of dehydrodolichyl diphosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of dehydrodolichyl diphosphate synthase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    dehydrodolichyl diphosphate synthase complex subunit Nus1
    Names
    Nogo-B receptor
    dehydrodolichyl diphosphate syntase complex subunit Nus1
    di-trans,poly-cis-decaprenylcistransferase
    ngBR
    nuclear undecaprenyl pyrophosphate synthase 1 homolog
    NP_084526.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030250.2NP_084526.1  dehydrodolichyl diphosphate synthase complex subunit Nus1

      See identical proteins and their annotated locations for NP_084526.1

      Status: VALIDATED

      Source sequence(s)
      AC153526
      Consensus CDS
      CCDS23841.1
      UniProtKB/Swiss-Prot
      Q99LJ8
      Related
      ENSMUSP00000023830.9, ENSMUST00000023830.16
      Conserved Domains (1) summary
      COG0020
      Location:124297
      UppS; Undecaprenyl pyrophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      52293643..52316288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)