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    Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit [ Mus musculus (house mouse) ]

    Gene ID: 52014, updated on 2-Oct-2018

    Summary

    Official Symbol
    Nus1provided by MGI
    Official Full Name
    NUS1 dehydrodolichyl diphosphate synthase subunitprovided by MGI
    Primary source
    MGI:MGI:1196365
    See related
    Ensembl:ENSMUSG00000023068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU019165; AW538011; BC003223; D10Ertd438e; 1600027K07Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 26.3), adrenal adult (RPKM 18.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nus1 in Genome Data Viewer
    Location:
    10 B3; 10 26.64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (52417547..52440192)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (52137353..52159998)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 10 Neighboring gene nephrocan Neighboring gene zinc finger protein, autosomal, pseudogene Neighboring gene predicted gene, 36065

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7199

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dehydrodolichyl diphosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    prenyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to prenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dolichol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    dolichyl diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein mannosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intracellular cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    sterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    dehydrodolichyl diphosphate synthase complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    dehydrodolichyl diphosphate synthase complex subunit Nus1
    Names
    Nogo-B receptor
    dehydrodolichyl diphosphate syntase complex subunit Nus1
    di-trans,poly-cis-decaprenylcistransferase
    ngBR
    nuclear undecaprenyl pyrophosphate synthase 1 homolog
    NP_084526.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030250.2NP_084526.1  dehydrodolichyl diphosphate synthase complex subunit Nus1

      See identical proteins and their annotated locations for NP_084526.1

      Status: VALIDATED

      Source sequence(s)
      AC153526
      Consensus CDS
      CCDS23841.1
      UniProtKB/Swiss-Prot
      Q99LJ8
      Related
      ENSMUSP00000023830.8, ENSMUST00000023830.15
      Conserved Domains (1) summary
      COG0020
      Location:124297
      UppS; Undecaprenyl pyrophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      52417547..52440192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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