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    Knstrn kinetochore-localized astrin/SPAG5 binding [ Mus musculus (house mouse) ]

    Gene ID: 51944, updated on 23-Jun-2021

    Summary

    Official Symbol
    Knstrnprovided by MGI
    Official Full Name
    kinetochore-localized astrin/SPAG5 bindingprovided by MGI
    Primary source
    MGI:MGI:1289298
    See related
    Ensembl:ENSMUSG00000027331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKAP; C15orf23; Traf4af1; D2Ertd750; D2Ertd750e; 1700025D04Rik
    Expression
    Broad expression in testis adult (RPKM 18.2), CNS E11.5 (RPKM 17.7) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Knstrn in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118644470..118667691)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118813988..118837210)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118639739..118661948)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dispatched RND tramsporter family member 2 Neighboring gene predicted gene, 38629 Neighboring gene predicted gene, 39913 Neighboring gene isovaleryl coenzyme A dehydrogenase Neighboring gene predicted gene, 32798

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    small kinetochore-associated protein
    Names
    TRAF4 associated factor 1 homolog
    TRAF4-associated factor 1
    kinastrin
    kinetochore-localized astrin-binding protein
    kinetochore-localized astrin/SPAG5-binding protein
    putative TRAF4-associated factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026412.3NP_080688.2  small kinetochore-associated protein

      See identical proteins and their annotated locations for NP_080688.2

      Status: VALIDATED

      Source sequence(s)
      AK006328, AK028590, AK036374
      Consensus CDS
      CCDS16585.1
      UniProtKB/Swiss-Prot
      Q9D9Z1
      Related
      ENSMUSP00000115860.2, ENSMUST00000134661.8
      Conserved Domains (1) summary
      PRK12704
      Location:144308
      PRK12704; phosphodiesterase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118644470..118667691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319123.2XP_017174612.1  small kinetochore-associated protein isoform X1

      Conserved Domains (1) summary
      pfam12128
      Location:127272
      DUF3584; Protein of unknown function (DUF3584)

    RNA

    1. XR_374488.4 RNA Sequence

    2. XR_374487.4 RNA Sequence

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