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    Ccnc cyclin C [ Mus musculus (house mouse) ]

    Gene ID: 51813, updated on 31-Aug-2021

    Summary

    Official Symbol
    Ccncprovided by MGI
    Official Full Name
    cyclin Cprovided by MGI
    Primary source
    MGI:MGI:1858199
    See related
    Ensembl:ENSMUSG00000028252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CG1C; AI451004; AU020987
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.3), CNS E14 (RPKM 4.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ccnc in Genome Data Viewer
    Location:
    4; 4 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21727701..21759922)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21727701..21759922)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (21654850..21677693)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene PR domain containing 13 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene PNN interacting serine/arginine-rich

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-C
    Names
    dJ199J3.4 (cyclin C)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122982.2NP_001116454.1  cyclin-C isoform 2

      See identical proteins and their annotated locations for NP_001116454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' exon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter by an amino acid and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK009615, AK037957, AK135472, AK153035, BQ175960
      Consensus CDS
      CCDS51127.1
      UniProtKB/TrEMBL
      Q3U6Q7, Q3UXL9, Q8CAS3
      Related
      ENSMUSP00000103875.3, ENSMUST00000108240.3
      Conserved Domains (2) summary
      cd20513
      Location:40146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
    2. NM_001290420.1NP_001277349.1  cyclin-C isoform 3

      See identical proteins and their annotated locations for NP_001277349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK037957, AK135472, BE653196
      Consensus CDS
      CCDS71350.1
      UniProtKB/TrEMBL
      Q3UXL9, Q8CAS3
      Related
      ENSMUSP00000113682.2, ENSMUST00000120679.8
      Conserved Domains (1) summary
      cl28538
      Location:1212
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
    3. NM_001290422.1NP_001277351.1  cyclin-C isoform 2

      See identical proteins and their annotated locations for NP_001277351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter by an amino acid and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK037957, AL772187, BC120649
      Consensus CDS
      CCDS51127.1
      UniProtKB/Swiss-Prot
      Q62447
      UniProtKB/TrEMBL
      Q8CAS3
      Related
      ENSMUSP00000069076.5, ENSMUST00000065928.11
      Conserved Domains (2) summary
      cd20513
      Location:40146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
    4. NM_016746.4NP_058026.2  cyclin-C isoform 1

      See identical proteins and their annotated locations for NP_058026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK037957, AL772187, BC120649
      Consensus CDS
      CCDS17998.1
      UniProtKB/Swiss-Prot
      Q62447
      UniProtKB/TrEMBL
      Q8CAS3
      Related
      ENSMUSP00000100062.2, ENSMUST00000102997.8
      Conserved Domains (2) summary
      cd20513
      Location:40146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      21727701..21759922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164233.1XP_036020126.1  cyclin-C isoform X1

      Conserved Domains (2) summary
      cd20513
      Location:33139
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:147238
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
    2. XM_036164234.1XP_036020127.1  cyclin-C isoform X2

      Conserved Domains (2) summary
      cd20513
      Location:33139
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:147238
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
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