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    Mcrs1 microspherule protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 51812, updated on 16-Oct-2021

    Summary

    Official Symbol
    Mcrs1provided by MGI
    Official Full Name
    microspherule protein 1provided by MGI
    Primary source
    MGI:MGI:1858420
    See related
    Ensembl:ENSMUSG00000037570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P78; MSP58; C78274; ICP22BP
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 38.4), testis adult (RPKM 37.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mcrs1 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99140698..99149842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99242817..99251961, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99073248..99082392, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a-like Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 25183 Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103140, MGC117915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microspherule protein 1
    Names
    58 kDa microspherule protein
    nucleolar protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164156.1NP_001157628.1  microspherule protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001157628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK167242, BC085099, CN724575
      Consensus CDS
      CCDS49728.1
      UniProtKB/Swiss-Prot
      Q99L90
      UniProtKB/TrEMBL
      Q3TJY1
      Related
      ENSMUSP00000131407.2, ENSMUST00000163506.3
      Conserved Domains (2) summary
      cd00060
      Location:332432
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:121318
      MCRS_N; N-terminal region of micro-spherule protein
    2. NM_016766.3NP_058046.2  microspherule protein 1 isoform 1

      See identical proteins and their annotated locations for NP_058046.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158347, BC085099, CN724575
      Consensus CDS
      CCDS37199.1
      UniProtKB/Swiss-Prot
      Q99L90
      UniProtKB/TrEMBL
      Q3TYU7
      Related
      ENSMUSP00000043901.10, ENSMUST00000041190.17
      Conserved Domains (2) summary
      cd00060
      Location:345445
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:134331
      MCRS_N; N-terminal region of micro-spherule protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99140698..99149842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248640.2XP_030104500.1  microspherule protein 1 isoform X1

      Conserved Domains (2) summary
      cd00060
      Location:345445
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:134331
      MCRS_N; N-terminal region of micro-spherule protein
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