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    Mcrs1 microspherule protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 51812, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mcrs1provided by MGI
    Official Full Name
    microspherule protein 1provided by MGI
    Primary source
    MGI:MGI:1858420
    See related
    Ensembl:ENSMUSG00000037570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P78; MSP58; C78274; ICP22BP
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 38.4), testis adult (RPKM 37.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mcrs1 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (99242817..99251961, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99073248..99082392, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene predicted gene, 34338 Neighboring gene predicted gene, 34447 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103140, MGC117915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K16 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity (H4-K16 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K5 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity (H4-K5 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K8 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity (H4-K8 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    telomerase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microspherule protein 1
    Names
    58 kDa microspherule protein
    nucleolar protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164156.1NP_001157628.1  microspherule protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001157628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK167242, BC085099, CN724575
      Consensus CDS
      CCDS49728.1
      UniProtKB/Swiss-Prot
      Q99L90
      UniProtKB/TrEMBL
      Q3TJY1
      Related
      ENSMUSP00000131407.1, ENSMUST00000163506.2
      Conserved Domains (2) summary
      cd00060
      Location:332432
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:121318
      MCRS_N; N-terminal region of micro-spherule protein
    2. NM_016766.3NP_058046.2  microspherule protein 1 isoform 1

      See identical proteins and their annotated locations for NP_058046.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158347, BC085099, CN724575
      Consensus CDS
      CCDS37199.1
      UniProtKB/Swiss-Prot
      Q99L90
      UniProtKB/TrEMBL
      Q3TYU7
      Related
      ENSMUSP00000043901.9, ENSMUST00000041190.16
      Conserved Domains (2) summary
      cd00060
      Location:345445
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:134331
      MCRS_N; N-terminal region of micro-spherule protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      99242817..99251961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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