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    Hnrnpu heterogeneous nuclear ribonucleoprotein U [ Mus musculus (house mouse) ]

    Gene ID: 51810, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hnrnpuprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Uprovided by MGI
    Primary source
    MGI:MGI:1858195
    See related
    Ensembl:ENSMUSG00000039630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hn; Sp1; SAFA; Hnrpu; Sp120; C86794; hnRNP U; AA408410; AI256620; AL024194; AL024437; AW557595
    Expression
    Broad expression in CNS E11.5 (RPKM 88.9), CNS E14 (RPKM 47.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hnrnpu in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178148673..178170063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178321108..178338891, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (180258431..180267915, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46174 Neighboring gene RIKEN cDNA B230369F24 gene Neighboring gene cytochrome c oxidase assembly protein 20 Neighboring gene predicted gene, 24919 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene predicted gene, 53484

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II C-terminal domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II C-terminal domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIIH-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TFIIH-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(C) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(C) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA localization to chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to leukemia inhibitory factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic transport of messenger ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic transport of messenger ribonucleoprotein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dosage compensation by inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect mRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in inactive sex chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in inactive sex chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inactive sex chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein U
    Names
    heterogenous nuclear ribonucleoprotein U
    nuclear matrix protein sp120
    scaffold attachment factor A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016805.3NP_058085.2  heterogeneous nuclear ribonucleoprotein U

      See identical proteins and their annotated locations for NP_058085.2

      Status: VALIDATED

      Source sequence(s)
      AC166710, AK049600, AK145499, AW123430, BY766801, CX567350
      Consensus CDS
      CCDS35804.1
      UniProtKB/Swiss-Prot
      Q8VEK3
      Related
      ENSMUSP00000047571.8, ENSMUST00000037748.9
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain

    RNA

    1. NR_149827.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA168064, AC166710, AK029944, AK040295, AK153188, BE650851, BY766801

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      178148673..178170063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152317.1XP_036008210.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      Related
      ENSMUSP00000124147.2, ENSMUST00000161769.8
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    2. XM_036152315.1XP_036008208.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    3. XM_036152313.1XP_036008206.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    4. XM_036152312.1XP_036008205.1  heterogeneous nuclear ribonucleoprotein U isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
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