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    RSF1 remodeling and spacing factor 1 [ Homo sapiens (human) ]

    Gene ID: 51773, updated on 7-Apr-2024

    Summary

    Official Symbol
    RSF1provided by HGNC
    Official Full Name
    remodeling and spacing factor 1provided by HGNC
    Primary source
    HGNC:HGNC:18118
    See related
    Ensembl:ENSG00000048649 MIM:608522; AllianceGenome:HGNC:18118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XAP8; p325; HBXAP; RSF-1
    Summary
    This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RSF1 in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77660009..77872232, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77593084..77805458, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77371054..77531768, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77348567-77349086 Neighboring gene uncharacterized LOC107984369 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4537 Neighboring gene chloride nucleotide-sensitive channel 1A Neighboring gene MPRA-validated peak1363 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:77464243-77464827 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:77464828-77465411 Neighboring gene RSF1 intronic transcript 1 Neighboring gene ferritin heavy chain 1 pseudogene 16 Neighboring gene UPF0764 protein C16orf89-like Neighboring gene MPRA-validated peak1365 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77530149-77531122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3803 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77531123-77532095 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene integrator complex subunit 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77643873-77644620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77644621-77645367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3804 Neighboring gene MPRA-validated peak1367 silencer Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77727696-77728196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77733111-77733678 Neighboring gene uncharacterized LOC124902723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77733679-77734248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77734249-77734816 Neighboring gene potassium channel tetramerization domain containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone octamer slider activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RSF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RSF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    remodeling and spacing factor 1
    Names
    HBV pX-associated protein 8
    hepatitis B virus x-associated protein
    p325 subunit of RSF chromatin-remodeling complex

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016578.4NP_057662.3  remodeling and spacing factor 1

      See identical proteins and their annotated locations for NP_057662.3

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP000609, AP002343
      Consensus CDS
      CCDS8253.1
      UniProtKB/Swiss-Prot
      Q86X86, Q96T23, Q9H3L8, Q9NVZ8, Q9NYU0
      Related
      ENSP00000311513.6, ENST00000308488.11
      Conserved Domains (5) summary
      cd15543
      Location:893938
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam02724
      Location:10931171
      CDC45; CDC45-like protein
      pfam15612
      Location:98148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:150182
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      cl02608
      Location:915968
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      77660009..77872232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017923.2XP_016873412.1  remodeling and spacing factor 1 isoform X2

      Related
      ENSP00000434509.1, ENST00000480887.5
    2. XM_005274051.3XP_005274108.1  remodeling and spacing factor 1 isoform X1

      Conserved Domains (5) summary
      cd15543
      Location:890935
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam02724
      Location:10901168
      CDC45; CDC45-like protein
      pfam15612
      Location:98148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:150182
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      cl02608
      Location:912965
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      77593084..77805458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369128.1XP_054225103.1  remodeling and spacing factor 1 isoform X2

    2. XM_054369127.1XP_054225102.1  remodeling and spacing factor 1 isoform X1