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    DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 [ Homo sapiens (human) ]

    Gene ID: 51726, updated on 8-Jul-2021

    Summary

    Official Symbol
    DNAJB11provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B11provided by HGNC
    Primary source
    HGNC:HGNC:14889
    See related
    Ensembl:ENSG00000090520 MIM:611341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ9; EDJ; Dj-9; ERj3; PKD6; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080
    Summary
    This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 37.3), appendix (RPKM 33.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DNAJB11 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186570720..186585793)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186288509..186303582)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene crystallin gamma S Neighboring gene TBCC domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 9080 Neighboring gene uncharacterized LOC100287402 Neighboring gene alpha 2-HS glycoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJB11; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
    env HIV-1 gp160 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of chaperone complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 11
    Names
    APOBEC1-binding protein 2
    DnaJ (Hsp40) homolog, subfamily B, member 11
    DnaJ protein 9
    ER-associated DNAJ protein 3
    ER-associated Hsp40 co-chaperone
    ER-resident protein ERdj3
    PWP1-interacting protein 4
    endoplasmic reticulum DNA J domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034024.1 RefSeqGene

      Range
      5001..20125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001378451.1NP_001365380.1  dnaJ homolog subfamily B member 11 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Conserved Domains (1) summary
      COG0484
      Location:22252
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_016306.6NP_057390.1  dnaJ homolog subfamily B member 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC068631
      Consensus CDS
      CCDS3277.1
      UniProtKB/Swiss-Prot
      Q9UBS4
      Related
      ENSP00000265028.3, ENST00000265028.8
      Conserved Domains (1) summary
      COG0484
      Location:22344
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_165638.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Related
      ENST00000680338.1
    2. NR_165639.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631
    3. NR_165640.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631
    4. NR_165641.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631
    5. NR_165642.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631
    6. NR_165643.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068631

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      186570720..186585793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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